| 01 Sept 22 | R. Street Robert Street |  Crystal PalaceCRY | → |  Shrewsbury TownSHR | Loan |
| 26 Aug 22 | L. Plange Luke Plange | Crystal PalaceCRY | → | RMXRWD MolenbeekRWD Molenbeek | Loan |
| 26 Aug 22 | J. O'Brien Jake O'Brien | Crystal PalaceCRY | → | RMXRWD MolenbeekRWD Molenbeek | Loan |
| 14 Aug 22 | C. Kouyaté Cheikhou Kouyaté | Crystal PalaceCRY | → |  Nottingham ForestNFO | Free |
| 11 Aug 22 | J. Rak-Sakyi Jesurun Rak-Sakyi | Crystal PalaceCRY | → |  Charlton AthleticCHA | Loan |
| 08 Aug 22 | S. Banks Scott Banks | Crystal PalaceCRY | → |  Bradford CityBRD | Loan |
| 05 Aug 22 | C. Benteke Christian Benteke | Crystal PalaceCRY | → |  D.C. UnitedDC | Undisclosed |
| 27 Jul 22 | C. Richards Chris Richards |  Bayern MunichMUN | → | Crystal PalaceCRY | Undisclosed |
| 27 Jul 22 | T. Adaramola Tayo Adaramola | Crystal PalaceCRY | → |  Coventry CityCOV | Loan |
| 27 Jul 22 | R. Matthews Remi Matthews | Crystal PalaceCRY | → |  St JohnstoneSTJO | Loan |
| 11 Jul 22 | C. Doucoure Cheick Oumar Doucoure |  LensRCL | → | Crystal PalaceCRY | Undisclosed |
| 01 Jul 22 | M. Ebiowei Malcolm Ebiowei |  Derby CountyDER | → | Crystal PalaceCRY | Undisclosed |
| 01 Jul 22 | S. Johnstone Sam Johnstone |  West Bromwich AlbionWBA | → | Crystal PalaceCRY | Free |
| 31 Jan 22 | L. Plange Luke Plange | Derby CountyDER | → | Crystal PalaceCRY | Undisclosed |
| 31 Jan 22 | L. Plange Luke Plange | Crystal PalaceCRY | → | Derby CountyDER | Loan |
| 31 Jan 22 | J. Mateta Jean-Philippe Mateta |  MainzM05 | → | Crystal PalaceCRY | Undisclosed |
| 26 Jan 22 | O. Webber Oliver Webber | Crystal PalaceCRY | → |  PortsmouthPOR | Undisclosed |
| 26 Jan 22 | R. Street Robert Street | Crystal PalaceCRY | → |  Newport CountyNEW | Loan |
| 14 Jan 22 | J. Rich-Baghuelou Jay Rich-Baghuelou | Crystal PalaceCRY | → |  Accrington StanleyACC | Undisclosed |
| 04 Jan 22 | J. O'Brien Jake O'Brien | Crystal PalaceCRY | → |  Swindon TownSWI | Loan |