| 31 Aug 21 | A. Collado Alex Collado |  BarcelonaBAR | → |  Sheffield UnitedSHU | Loan |
| 31 Aug 21 | R. Olsen Robin Olsen |  AS RomaROMA | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | A. Collado Alex Collado | BarcelonaBAR | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White |  Wolverhampton WanderersWOL | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | R. Olsen Robin Olsen | AS RomaROMA | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White | Wolverhampton WanderersWOL | → | Sheffield UnitedSHU | Loan |
| 30 Aug 21 | C. Hourihane Conor Hourihane |  Aston VillaAVL | → | Sheffield UnitedSHU | Loan |
| 30 Aug 21 | C. Hourihane Conor Hourihane | Aston VillaAVL | → | Sheffield UnitedSHU | Loan |
| 20 Aug 21 | A. Ramsdale Aaron Ramsdale | Sheffield UnitedSHU | → |  ArsenalARS | Undisclosed |
| 20 Aug 21 | A. Ramsdale Aaron Ramsdale | Sheffield UnitedSHU | → | ArsenalARS | Undisclosed |
| 16 Aug 21 | B. Davies Ben Davies |  LiverpoolLIV | → | Sheffield UnitedSHU | Loan |
| 16 Aug 21 | B. Davies Ben Davies | LiverpoolLIV | → | Sheffield UnitedSHU | Loan |
| 01 Feb 21 | M. Verrips Michael Verrips | Sheffield UnitedSHU | → |  FC EmmenEMM | Loan |
| 01 Feb 21 | J. Eastwood Jake Eastwood | Sheffield UnitedSHU | → |  Grimsby TownGRI | Loan |
| 01 Feb 21 | M. Verrips Michael Verrips | Sheffield UnitedSHU | → | FC EmmenEMM | Loan |
| 12 Jan 21 | R. Norrington-Davies Rhys Norrington-Davies | Sheffield UnitedSHU | → |  Stoke CitySTK | Loan |
| 12 Jan 21 | R. Norrington-Davies Rhys Norrington-Davies | Sheffield UnitedSHU | → | Stoke CitySTK | Loan |