| 31 Aug 21 | M. Pongracic Marin Pongracic |  VfL WolfsburgWOB | → |  Borussia DortmundDOR | Loan |
| 25 Aug 21 | T. Delaney Thomas Delaney | Borussia DortmundDOR | → |  SevillaSEV | Undisclosed |
| 25 Aug 21 | T. Delaney Thomas Delaney | Borussia DortmundDOR | → | SevillaSEV | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen |  PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 23 Jul 21 | J. Sancho Jadon Sancho | Borussia DortmundDOR | → |  Manchester UnitedMAN | Undisclosed |
| 23 Jul 21 | J. Sancho Jadon Sancho | Borussia DortmundDOR | → | Manchester UnitedMAN | Undisclosed |
| 20 Jul 21 | A. Kamara Abdoulaye Kamara |  Paris Saint-Germain PSG | → | Borussia DortmundDOR | Undisclosed |
| 20 Jul 21 | A. Kamara Abdoulaye Kamara | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Undisclosed |
| 03 Jul 21 | L. Balerdi Leonardo Balerdi | Borussia DortmundDOR | → |  MarseilleMAR | Undisclosed |
| 03 Jul 21 | L. Balerdi Leonardo Balerdi | Borussia DortmundDOR | → | MarseilleMAR | Undisclosed |
| 01 Jul 21 | S. Gómez Sergio Gómez | Borussia DortmundDOR | → |  AnderlechtAND | Undisclosed |
| 01 Jul 21 | Soumaila Coulibaly | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Free |
| 01 Jul 21 | L. Piszczek Lukasz Piszczek | Borussia DortmundDOR | → | GXXGoczalkowiceGoczalkowice | Free |
| 01 Jul 21 | Soumaila Coulibaly | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Free |
| 01 Jul 21 | J. Toljan Jeremy Toljan | Borussia DortmundDOR | → |  SassuoloSAS | Undisclosed |
| 01 Jul 21 | J. Toljan Jeremy Toljan | Borussia DortmundDOR | → | SassuoloSAS | Undisclosed |
| 01 Jul 21 | G. Kobel Gregor Kobel |  VfB StuttgartVFB | → | Borussia DortmundDOR | Undisclosed |