| 31 Aug 21 | C. Carter-Vickers Cameron Carter-Vickers |  Tottenham HotspurTOT | → |  CelticCEL | Loan |
| 31 Aug 21 | J. Lloyd-Bennett J'Meill Lloyd-Bennett | Tottenham HotspurTOT | → |  Crewe AlexandraCREW | Loan |
| 31 Aug 21 | E. Royal Emerson Royal |  BarcelonaBAR | → | Tottenham HotspurTOT | 25000000 |
| 31 Aug 21 | C. Carter-Vickers Cameron Carter-Vickers | Tottenham HotspurTOT | → | CelticCEL | Loan |
| 31 Aug 21 | E. Royal Emerson Royal | BarcelonaBAR | → | Tottenham HotspurTOT | 25000000 |
| 27 Aug 21 | P. Sarr Pape Sarr | Tottenham HotspurTOT | → |  MetzMETZ | Loan |
| 27 Aug 21 | P. Sarr Pape Sarr | MetzMETZ | → | Tottenham HotspurTOT | Undisclosed |
| 27 Aug 21 | M. Sissoko Moussa Sissoko | Tottenham HotspurTOT | → |  WatfordWAT | Undisclosed |
| 27 Aug 21 | P. Sarr Pape Sarr | MetzMETZ | → | Tottenham HotspurTOT | Undisclosed |
| 27 Aug 21 | P. Sarr Pape Sarr | Tottenham HotspurTOT | → | MetzMETZ | Loan |
| 17 Aug 21 | T. Eyoma Timothy Eyoma | Tottenham HotspurTOT | → |  Lincoln CityLCN | Undisclosed |
| 12 Aug 21 | A. Whiteman Alfie Whiteman | Tottenham HotspurTOT | → |  Degerfors IFDEG | Loan |
| 11 Aug 21 | D. Cirkin Dennis Cirkin | Tottenham HotspurTOT | → |  SunderlandSUN | Undisclosed |
| 07 Aug 21 | J. Bowden Jamie Bowden | Tottenham HotspurTOT | → |  Oldham AthleticOLD | Loan |
| 06 Aug 21 | C. Romero Cristian Romero |  AtalantaATA | → | Tottenham HotspurTOT | Loan |
| 06 Aug 21 | C. Romero Cristian Romero | AtalantaATA | → | Tottenham HotspurTOT | Loan |
| 05 Aug 21 | J. Okedina Jubril Adesope Okedina | Tottenham HotspurTOT | → |  Cambridge UnitedCAMB | Undisclosed |
| 03 Aug 21 | J. Hart Joe Hart | Tottenham HotspurTOT | → | CelticCEL | Undisclosed |
| 03 Aug 21 | J. Hart Joe Hart | Tottenham HotspurTOT | → | CelticCEL | Undisclosed |
| 02 Aug 21 | K. Etete Kion Etete | Tottenham HotspurTOT | → |  Northampton TownNHT | Loan |
| 29 Jul 21 | T. Parrott Troy Parrott | Tottenham HotspurTOT | → |  Milton Keynes DonsMKD | Loan |
| 27 Jul 21 | T. Alderweireld Toby Alderweireld | Tottenham HotspurTOT | → | ASXAl-Duhail SCAl-Duhail SC | Undisclosed |
| 26 Jul 21 | E. Lamela Erik Lamela | Tottenham HotspurTOT | → |  SevillaSEV | Undisclosed |
| 26 Jul 21 | B. Gil Bryan Gil | SevillaSEV | → | Tottenham HotspurTOT | Undisclosed |
| 26 Jul 21 | B. Gil Bryan Gil | SevillaSEV | → | Tottenham HotspurTOT | Undisclosed |
| 26 Jul 21 | E. Lamela Erik Lamela | Tottenham HotspurTOT | → | SevillaSEV | Undisclosed |
| 24 Jul 21 | P. Gollini Pierluigi Gollini | AtalantaATA | → | Tottenham HotspurTOT | Loan |
| 24 Jul 21 | P. Gazzaniga Paulo Gazzaniga | Tottenham HotspurTOT | → |  FulhamFUL | Free |
| 24 Jul 21 | P. Gazzaniga Paulo Gazzaniga | Tottenham HotspurTOT | → | FulhamFUL | Free |
| 24 Jul 21 | P. Gollini Pierluigi Gollini | AtalantaATA | → | Tottenham HotspurTOT | Loan |
| 01 Jul 21 | J. Foyth Juan Foyth | Tottenham HotspurTOT | → |  VillarrealVIL | Undisclosed |
| 01 Jul 21 | J. Foyth Juan Foyth | Tottenham HotspurTOT | → | VillarrealVIL | Undisclosed |
| 01 Jul 21 | D. Rose Danny Rose | Tottenham HotspurTOT | → | WatfordWAT | Free |
| 01 Feb 21 | J. Roles Jack Roles | Tottenham HotspurTOT | → |  StevenageSTE | Loan |
| 01 Feb 21 | P. Gazzaniga Paulo Gazzaniga | Tottenham HotspurTOT | → |  ElcheELC | Loan |
| 01 Feb 21 | P. Gazzaniga Paulo Gazzaniga | Tottenham HotspurTOT | → | ElcheELC | Loan |
| 01 Feb 21 | T. Parrott Troy Parrott | Tottenham HotspurTOT | → |  Ipswich TownIPS | Loan |
| 31 Jan 21 | M. Pochettino Maurizio Pochettino | Tottenham HotspurTOT | → | WatfordWAT | Undisclosed |
| 31 Jan 21 | M. Pochettino Maurizio Pochettino | Tottenham HotspurTOT | → | WatfordWAT | Undisclosed |
| 25 Jan 21 | S. Tracey Shilow Tracey | Tottenham HotspurTOT | → | Cambridge UnitedCAMB | Loan |
| 22 Jan 21 | B. Austin Brandon Austin | Tottenham HotspurTOT | → |  Orlando City SCORL | Loan |
| 22 Jan 21 | B. Austin Brandon Austin | Tottenham HotspurTOT | → | Orlando City SCORL | Loan |
| 21 Jan 21 | A. Georgiou Anthony Georgiou | Tottenham HotspurTOT | → | ALXAEL LimassolAEL Limassol | Undisclosed |
| 18 Jan 21 | H. White Harvey White | Tottenham HotspurTOT | → |  PortsmouthPOR | Loan |
| 14 Jan 21 | J. Clarke Jack Clarke | Tottenham HotspurTOT | → |  Stoke CitySTK | Loan |
| 14 Jan 21 | J. Clarke Jack Clarke | Tottenham HotspurTOT | → | Stoke CitySTK | Loan |
| 06 Jan 21 | J. Okedina Jubril Adesope Okedina | Tottenham HotspurTOT | → | Cambridge UnitedCAMB | Loan |