| 31 Aug 22 | Will Lankshear |  Sheffield UnitedSHU | → |  Tottenham HotspurTOT | Undisclosed |
| 30 Aug 22 | H. Winks Harry Winks | Tottenham HotspurTOT | → |  SampdoriaSAM | Loan |
| 30 Aug 22 | S. Reguilón Sergio Reguilón | Tottenham HotspurTOT | → |  Atletico MadridATM | Loan |
| 30 Aug 22 | C. Romero Cristian Romero |  AtalantaATA | → | Tottenham HotspurTOT | Undisclosed |
| 19 Aug 22 | T. Ndombele Tanguy Ndombele | Tottenham HotspurTOT | → |  NapoliNAP | Loan |
| 16 Aug 22 | D. Udogie Destiny Udogie | Tottenham HotspurTOT | → |  UdineseUDI | Loan |
| 16 Aug 22 | D. Udogie Destiny Udogie | UdineseUDI | → | Tottenham HotspurTOT | Undisclosed |
| 14 Aug 22 | G. Lo Celso Giovani Lo Celso | Tottenham HotspurTOT | → |  VillarrealVIL | Loan |
| 09 Aug 22 | T. Lo-Tutala Thimothee Lo-Tutala | Tottenham HotspurTOT | → |  Hull CityHUL | Undisclosed |
| 04 Aug 22 | K. Etete Kion Etete | Tottenham HotspurTOT | → |  Cardiff CityCAR | Undisclosed |
| 01 Aug 22 | J. Rodon Joe Rodon | Tottenham HotspurTOT | → |  Stade RennaisREN | Loan |
| 27 Jul 22 | D. Scarlett Dane Scarlett | Tottenham HotspurTOT | → |  PortsmouthPOR | Loan |
| 25 Jul 22 | T. Parrott Troy Parrott | Tottenham HotspurTOT | → |  Preston North EndPNE | Loan |
| 19 Jul 22 | D. Spence Djed Spence |  MiddlesbroughMID | → | Tottenham HotspurTOT | Undisclosed |
| 09 Jul 22 | J. Clarke Jack Clarke | Tottenham HotspurTOT | → |  SunderlandSUN | Undisclosed |
| 08 Jul 22 | C. Lenglet Clément Lenglet |  BarcelonaBAR | → | Tottenham HotspurTOT | Loan |
| 08 Jul 22 | S. Bergwijn Steven Bergwijn | Tottenham HotspurTOT | → |  Ajax AmsterdamAJA | Undisclosed |
| 01 Jul 22 | C. Carter-Vickers Cameron Carter-Vickers | Tottenham HotspurTOT | → |  CelticCEL | Undisclosed |
| 01 Jul 22 | I. Perisic Ivan Perisic |  InternazionaleINT | → | Tottenham HotspurTOT | Free |
| 01 Jul 22 | F. Forster Fraser Forster |  SouthamptonSOU | → | Tottenham HotspurTOT | Free |
| 01 Jul 22 | Richarlison |  EvertonEVE | → | Tottenham HotspurTOT | Undisclosed |
| 17 Jun 22 | Y. Bissouma Yves Bissouma |  Brighton & Hove AlbionBHA | → | Tottenham HotspurTOT | Undisclosed |
| 10 Feb 22 | A. Whiteman Alfie Whiteman | Tottenham HotspurTOT | → |  Degerfors IFDEG | Loan |
| 31 Jan 22 | T. Ndombele Tanguy Ndombele | Tottenham HotspurTOT | → |  LyonLYON | Loan |
| 31 Jan 22 | G. Lo Celso Giovani Lo Celso | Tottenham HotspurTOT | → | VillarrealVIL | Loan |
| 31 Jan 22 | D. Kulusevski Dejan Kulusevski |  JuventusJUV | → | Tottenham HotspurTOT | Loan |
| 31 Jan 22 | B. Gil Bryan Gil | Tottenham HotspurTOT | → |  ValenciaVAL | Loan |
| 31 Jan 22 | D. Alli Dele Alli | Tottenham HotspurTOT | → | EvertonEVE | Undisclosed |
| 31 Jan 22 | R. Bentancur Rodrigo Bentancur | JuventusJUV | → | Tottenham HotspurTOT | 19000000 |
| 27 Jan 22 | N. John Nile John | Tottenham HotspurTOT | → |  Charlton AthleticCHA | Loan |
| 26 Jan 22 | J. Clarke Jack Clarke | Tottenham HotspurTOT | → | SunderlandSUN | Loan |
| 18 Jan 22 | D. Markanday Dilan Kumar Markanday | Tottenham HotspurTOT | → |  Blackburn RoversBLK | Undisclosed |
| 17 Jan 22 | K. Etete Kion Etete | Tottenham HotspurTOT | → |  Cheltenham TownCHL | Loan |