| 31 Aug 21 | A. Lookman Ademola Lookman |  RB LeipzigRBL | → |  Leicester CityLEI | Loan |
| 31 Aug 21 | I. Moriba Ilaix Moriba |  BarcelonaBAR | → | RB LeipzigRBL | Undisclosed |
| 31 Aug 21 | A. Lookman Ademola Lookman | RB LeipzigRBL | → | Leicester CityLEI | Loan |
| 31 Aug 21 | I. Moriba Ilaix Moriba | BarcelonaBAR | → | RB LeipzigRBL | Undisclosed |
| 30 Aug 21 | M. Sabitzer Marcel Sabitzer | RB LeipzigRBL | → |  Bayern MunichMUN | Undisclosed |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → |  Wolverhampton WanderersWOL | Loan |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → | Wolverhampton WanderersWOL | Loan |
| 25 Aug 21 | A. Sørloth Alexander Sørloth | RB LeipzigRBL | → |  Real SociedadRSO | Loan |
| 25 Aug 21 | A. Sørloth Alexander Sørloth | RB LeipzigRBL | → | Real SociedadRSO | Loan |
| 05 Aug 21 | L. Samardzic Lazar Samardzic | RB LeipzigRBL | → |  LazioLAZ | Undisclosed |
| 05 Aug 21 | L. Samardzic Lazar Samardzic | RB LeipzigRBL | → | LazioLAZ | Undisclosed |
| 02 Jul 21 | A. Silva André Silva |  Eintracht FrankfurtSGE | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | F. Hartmann Fabrice Hartmann | RB LeipzigRBL | → |  SC Paderborn 07PAD | Loan |
| 01 Jul 21 | B. Brobbey Brian Brobbey |  Ajax AmsterdamAJA | → | RB LeipzigRBL | Free |
| 01 Jul 21 | Angeliño |  Manchester CityMNC | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | D. Upamecano Dayot Upamecano | RB LeipzigRBL | → | Bayern MunichMUN | 42500000 |
| 01 Jul 21 | I. Konaté Ibrahima Konaté | RB LeipzigRBL | → |  LiverpoolLIV | 41500000 |
| 01 Jul 21 | Angeliño | Manchester CityMNC | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | C. Clark Caden Clark |  New York Red BullsNY | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | J. Gvardiol Josko Gvardiol | DZXDinamo ZagrebDinamo Zagreb | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | B. Henrichs Benjamin Henrichs |  AS MonacoMON | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | M. Simakan Mohamed Simakan |  StrasbourgSTRA | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | H. Wolf Hannes Wolf | RB LeipzigRBL | → |  Borussia MonchengladbachMON | Undisclosed |
| 01 Jul 21 | B. Brobbey Brian Brobbey | Ajax AmsterdamAJA | → | RB LeipzigRBL | Free |
| 01 Jul 21 | C. Clark Caden Clark | RB LeipzigRBL | → | New York Red BullsNY | Loan |
| 01 Jul 21 | B. Henrichs Benjamin Henrichs | AS MonacoMON | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | M. Simakan Mohamed Simakan | StrasbourgSTRA | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | C. Clark Caden Clark | New York Red BullsNY | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | C. Clark Caden Clark | RB LeipzigRBL | → | New York Red BullsNY | Loan |
| 01 Jul 21 | I. Konaté Ibrahima Konaté | RB LeipzigRBL | → | LiverpoolLIV | 41500000 |
| 29 Jan 21 | D. Borkowski Dennis Borkowski | RB LeipzigRBL | → |  NurnbergNUR | Loan |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → |  VitesseVIT | Loan |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → | VitesseVIT | Loan |
| 15 Jan 21 | E. Martel Eric Martel | RB LeipzigRBL | → |  Austria ViennaVIE | Loan |
| 02 Jan 21 | D. Szoboszlai Dominik Szoboszlai |  FC SalzburgSLZ | → | RB LeipzigRBL | Undisclosed |