| 12 Sept 22 | L. Karius Loris Karius | XXX | → |  Newcastle UnitedNEW | Free |
| 01 Sept 22 | K. Watts Kelland Watts | Newcastle UnitedNEW | → |  Peterborough UnitedPET | Loan |
| 01 Sept 22 | M. Longstaff Matthew Longstaff | Newcastle UnitedNEW | → |  Colchester UnitedCOL | Loan |
| 01 Sept 22 | M. Dúbravka Martin Dúbravka | Newcastle UnitedNEW | → |  Manchester UnitedMAN | Loan |
| 01 Sept 22 | F. Fernández Federico Fernández | Newcastle UnitedNEW | → |  ElcheELC | Undisclosed |
| 26 Aug 22 | A. Isak Alexander Isak |  Real SociedadRSO | → | Newcastle UnitedNEW | Undisclosed |
| 22 Jul 22 | D. Gayle Dwight Gayle | Newcastle UnitedNEW | → |  Stoke CitySTK | Undisclosed |
| 13 Jul 22 | C. Clark Ciaran Clark | Newcastle UnitedNEW | → |  Sheffield UnitedSHU | Loan |
| 12 Jul 22 | J. Hendrick Jeff Hendrick | Newcastle UnitedNEW | → |  ReadingREA | Loan |
| 06 Jul 22 | C. Mcarthur Charlie Mcarthur |  KilmarnockKIL | → | Newcastle UnitedNEW | Undisclosed |
| 01 Jul 22 | M. Targett Matt Targett |  Aston VillaAVL | → | Newcastle UnitedNEW | Undisclosed |
| 01 Jul 22 | I. Hayden Isaac Hayden | Newcastle UnitedNEW | → |  Norwich CityNOR | Loan |
| 01 Jul 22 | J. Young Jack Young | Newcastle UnitedNEW | → |  Wycombe WanderersWYC | Undisclosed |
| 01 Jul 22 | S. Botman Sven Botman |  LilleLILL | → | Newcastle UnitedNEW | Undisclosed |
| 23 Jun 22 | N. Pope Nick Pope |  BurnleyBUR | → | Newcastle UnitedNEW | Undisclosed |
| 21 Jun 22 | F. Woodman Freddie Woodman | Newcastle UnitedNEW | → |  Preston North EndPNE | Undisclosed |
| 31 Jan 22 | J. Young Jack Young | Newcastle UnitedNEW | → | Wycombe WanderersWYC | Loan |
| 31 Jan 22 | F. Woodman Freddie Woodman | Newcastle UnitedNEW | → |  AFC BournemouthBOU | Loan |
| 31 Jan 22 | M. Targett Matt Targett | Aston VillaAVL | → | Newcastle UnitedNEW | Loan |
| 31 Jan 22 | M. Longstaff Matthew Longstaff | Newcastle UnitedNEW | → |  Mansfield TownMAN | Loan |
| 31 Jan 22 | J. Hendrick Jeff Hendrick | Newcastle UnitedNEW | → |  Queens Park RangersQPR | Loan |
| 31 Jan 22 | M. Bondswell Matthew Bondswell | Newcastle UnitedNEW | → |  Shrewsbury TownSHR | Loan |
| 31 Jan 22 | E. Anderson Elliot Anderson | Newcastle UnitedNEW | → |  Bristol RoversBRI | Loan |
| 31 Jan 22 | D. Burn Dan Burn |  Brighton & Hove AlbionBHA | → | Newcastle UnitedNEW | Undisclosed |
| 30 Jan 22 | B. Guimarães Bruno Guimarães |  LyonLYON | → | Newcastle UnitedNEW | 42100000 |
| 29 Jan 22 | J. White Joe White | Newcastle UnitedNEW | → |  Hartlepool UnitedHAR | Loan |
| 13 Jan 22 | C. Wood Chris Wood | BurnleyBUR | → | Newcastle UnitedNEW | Undisclosed |
| 07 Jan 22 | K. Trippier Kieran Trippier |  Atletico MadridATM | → | Newcastle UnitedNEW | Undisclosed |
| 07 Jan 22 | R. Longelo Rosarie Longelo | Newcastle UnitedNEW | → |  Accrington StanleyACC | Undisclosed |