| 03 Sept 21 | G. Vagiannidis Georgios Vagiannidis |  InternazionaleINT | → |  PanathinaikosPAO | Free |
| 31 Aug 21 | E. Vergani Edoardo Vergani | InternazionaleINT | → |  SalernitanaSAL | Undisclosed |
| 31 Aug 21 | L. Agoumé Lucien Agoumé | InternazionaleINT | → |  BrestBRES | Loan |
| 31 Aug 21 | V. Lazaro Valentino Lazaro | InternazionaleINT | → |  BenficaBEN | Loan |
| 31 Aug 21 | L. Agoumé Lucien Agoumé | InternazionaleINT | → | BrestBRES | Loan |
| 26 Aug 21 | J. Correa Joaquín Correa |  LazioLAZ | → | InternazionaleINT | Loan |
| 25 Aug 21 | A. Pinamonti Andrea Pinamonti | InternazionaleINT | → |  EmpoliEMP | Loan |
| 20 Aug 21 | T. Schirò Thomas Schirò | InternazionaleINT | → |  CrotoneCRO | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries |  PSV EindhovenPSV | → | InternazionaleINT | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries | PSV EindhovenPSV | → | InternazionaleINT | Undisclosed |
| 14 Aug 21 | E. Dzeko Edin Dzeko |  AS RomaROMA | → | InternazionaleINT | Undisclosed |
| 12 Aug 21 | R. Lukaku Romelu Lukaku | InternazionaleINT | → |  ChelseaCHE | Undisclosed |
| 12 Aug 21 | R. Lukaku Romelu Lukaku | InternazionaleINT | → | ChelseaCHE | Undisclosed |
| 11 Aug 21 | X. Emmers Xian Emmers | InternazionaleINT | → |  Roda JC KerkradeRJC | Free |
| 04 Aug 21 | F. Stankovic Filip Stankovic | InternazionaleINT | → |  FC VolendamVOL | Loan |
| 27 Jul 21 | S. Mulattieri Samuele Mulattieri | InternazionaleINT | → | CrotoneCRO | Loan |
| 21 Jul 21 | Dalbert | InternazionaleINT | → |  CagliariCAG | Loan |
| 20 Jul 21 | Z. Vanheusden Zinho Vanheusden | InternazionaleINT | → |  GenoaGEN | Loan |
| 14 Jul 21 | A. Gravillon Andreaw Gravillon | InternazionaleINT | → |  Stade de ReimsREIM | Loan |
| 14 Jul 21 | A. Gravillon Andreaw Gravillon | InternazionaleINT | → | Stade de ReimsREIM | Loan |
| 13 Jul 21 | S. Esposito Sebastiano Esposito | InternazionaleINT | → |  FC BaselBAS | Loan |
| 13 Jul 21 | João Mário | InternazionaleINT | → | BenficaBEN | Free |
| 09 Jul 21 | D. Males Darian Males | InternazionaleINT | → | FC BaselBAS | Loan |
| 06 Jul 21 | A. Hakimi Achraf Hakimi | InternazionaleINT | → |  Paris Saint-Germain PSG | Undisclosed |
| 06 Jul 21 | A. Hakimi Achraf Hakimi | InternazionaleINT | → | Paris Saint-Germain PSG | Undisclosed |
| 01 Jul 21 | M. Darmian Matteo Darmian |  ParmaPAR | → | InternazionaleINT | Undisclosed |
| 01 Jul 21 | A. Cordaz Alex Cordaz | CrotoneCRO | → | InternazionaleINT | Undisclosed |
| 01 Jul 21 | A. Candreva Antonio Candreva | InternazionaleINT | → |  SampdoriaSAM | Undisclosed |
| 01 Jul 21 | R. Rivas Rigoberto Rivas | InternazionaleINT | → |  RegginaREG | Undisclosed |
| 01 Jul 21 | A. Young Ashley Young | InternazionaleINT | → |  Aston VillaAVL | Free |
| 01 Jul 21 | L. Gavioli Lorenzo Gavioli | InternazionaleINT | → | RegginaREG | Loan |
| 01 Jul 21 | A. Young Ashley Young | InternazionaleINT | → | Aston VillaAVL | Free |
| 01 Jul 21 | D. Padelli Daniele Padelli | InternazionaleINT | → |  UdineseUDN | Free |
| 01 Jul 21 | H. Calhanoglu Hakan Calhanoglu |  AC MilanMIL | → | InternazionaleINT | Free |
| 01 Jul 21 | M. Politano Matteo Politano | InternazionaleINT | → |  NapoliNAP | Undisclosed |
| 15 Jan 21 | S. Esposito Sebastiano Esposito | InternazionaleINT | → |  VeneziaVEN | Loan |
| 11 Jan 21 | A. Bakayoko Axel Bakayoko | InternazionaleINT | → | RSBRed Star BelgradeRed Star Belgrade | Undisclosed |
| 04 Jan 21 | R. Nainggolan Radja Nainggolan | InternazionaleINT | → | CagliariCAG | Loan |