| 31 Aug 15 | J. Hernández Javier Hernández |  Manchester UnitedMAN | → |  Bayer LeverkusenLEV | Undisclosed |
| 31 Aug 15 | J. Hernández Javier Hernández | Manchester UnitedMAN | → | Bayer LeverkusenLEV | Undisclosed |
| 28 Aug 15 | S. Heung-Min Son Heung-Min | Bayer LeverkusenLEV | → |  Tottenham HotspurTOT | Undisclosed |
| 28 Aug 15 | P. Hojbjerg Pierre-Emile Hojbjerg |  Bayern MunichMUN | → | Bayer LeverkusenLEV | Loan |
| 28 Aug 15 | K. Kampl Kevin Kampl |  Borussia DortmundDOR | → | Bayer LeverkusenLEV | Undisclosed |
| 28 Aug 15 | S. Heung-Min Son Heung-Min | Bayer LeverkusenLEV | → | Tottenham HotspurTOT | Undisclosed |
| 20 Aug 15 | K. Stafylidis Konstantinos Stafylidis | Bayer LeverkusenLEV | → |  FC AugsburgAUG | Undisclosed |
| 13 Aug 15 | C. Aránguiz Charles Aránguiz |  InternacionalINT | → | Bayer LeverkusenLEV | Undisclosed |
| 13 Aug 15 | C. Aránguiz Charles Aránguiz | InternacionalINT | → | Bayer LeverkusenLEV | Undisclosed |
| 16 Jul 15 | J. Tah Jonathan Tah |  Hamburg SVHSV | → | Bayer LeverkusenLEV | Undisclosed |
| 01 Jul 15 | K. Papadopoulos Kyriakos Papadopoulos |  Schalke 04SCHA | → | Bayer LeverkusenLEV | Undisclosed |
| 01 Jul 15 | P. Wollscheid Philipp Wollscheid | Bayer LeverkusenLEV | → |  Stoke CitySTK | Undisclosed |
| 01 Jul 15 | G. Castro Gonzalo Castro | Bayer LeverkusenLEV | → | Borussia DortmundDOR | 11000000 |
| 01 Jul 15 | A. Milik Arkadiusz Milik | Bayer LeverkusenLEV | → |  Ajax AmsterdamAJA | Undisclosed |
| 01 Jul 15 | P. Wollscheid Philipp Wollscheid | Bayer LeverkusenLEV | → | Stoke CitySTK | Undisclosed |
| 01 Jul 15 | A. Ramalho André Ramalho |  RB LeipzigRBL | → | Bayer LeverkusenLEV | Free |
| 01 Jul 15 | S. Reinartz Stefan Reinartz | Bayer LeverkusenLEV | → |  Eintracht FrankfurtSGE | Free |
| 01 Jul 15 | A. Milik Arkadiusz Milik | Bayer LeverkusenLEV | → | Ajax AmsterdamAJA | Undisclosed |
| 18 Jun 15 | D. Kresic Dario Kresic | Bayer LeverkusenLEV | → |  Borussia MonchengladbachMON | Undisclosed |
| 11 Jun 15 | A. Mehmedi Admir Mehmedi |  SC FreiburgFREI | → | Bayer LeverkusenLEV | Undisclosed |
| 20 Jan 15 | T. Jedvaj Tin Jedvaj |  AS RomaROMA | → | Bayer LeverkusenLEV | Undisclosed |
| 20 Jan 15 | T. Jedvaj Tin Jedvaj | AS RomaROMA | → | Bayer LeverkusenLEV | Undisclosed |
| 07 Jan 15 | P. Wollscheid Philipp Wollscheid | Bayer LeverkusenLEV | → | Stoke CitySTK | Loan |
| 07 Jan 15 | P. Wollscheid Philipp Wollscheid | Bayer LeverkusenLEV | → | Stoke CitySTK | Loan |
| 01 Jan 15 | L. Öztunali Levin Öztunali | Bayer LeverkusenLEV | → |  Werder BremenWER | Loan |