| 10 Nov 12 | A. Seidi Alberto Seidi |  SouthamptonSOU | → |  Aldershot TownALD | Loan |
| 09 Nov 12 | D. Seaborne Daniel Seaborne | SouthamptonSOU | → |  Charlton AthleticCHA | Loan |
| 09 Nov 12 | D. Seaborne Daniel Seaborne | SouthamptonSOU | → | Charlton AthleticCHA | Loan |
| 22 Sept 12 | A. Boruc Artur Boruc | XXX | → | SouthamptonSOU | Free |
| 31 Aug 12 | B. Sharp Billy Sharp | SouthamptonSOU | → |  Nottingham ForestFOR | Loan |
| 31 Aug 12 | G. Ramírez Gastón Ramírez |  BolognaBOL | → | SouthamptonSOU | Undisclosed |
| 31 Aug 12 | Cody Cropper | XXX | → | SouthamptonSOU | Free |
| 31 Aug 12 | B. Sharp Billy Sharp | SouthamptonSOU | → | Nottingham ForestFOR | Loan |
| 31 Aug 12 | G. Ramírez Gastón Ramírez | BolognaBOL | → | SouthamptonSOU | Undisclosed |
| 30 Aug 12 | M. Yoshida Maya Yoshida |  VVV-VenloVVV | → | SouthamptonSOU | Undisclosed |
| 30 Aug 12 | M. Yoshida Maya Yoshida | VVV-VenloVVV | → | SouthamptonSOU | Undisclosed |
| 28 Aug 12 | E. Mayuka Emmanuel Mayuka |  Young BoysYB | → | SouthamptonSOU | Undisclosed |
| 17 Aug 12 | J. Forte Jonathan Forte | SouthamptonSOU | → |  Crawley TownCRA | Loan |
| 17 Aug 12 | L. Barnard Lee Barnard | SouthamptonSOU | → |  AFC BournemouthBOU | Loan |
| 28 Jul 12 | D. Harding Daniel Harding | SouthamptonSOU | → | Nottingham ForestFOR | Undisclosed |
| 28 Jul 12 | D. Harding Daniel Harding | SouthamptonSOU | → | Nottingham ForestFOR | Undisclosed |
| 27 Jul 12 | N. Clyne Nathaniel Clyne |  Crystal PalaceCRY | → | SouthamptonSOU | Undisclosed |
| 27 Jul 12 | N. Clyne Nathaniel Clyne | Crystal PalaceCRY | → | SouthamptonSOU | Undisclosed |
| 21 Jul 12 | S. Davis Steven Davis | RXXRangersRangers | → | SouthamptonSOU | Undisclosed |
| 21 Jul 12 | S. Davis Steven Davis | RXXRangersRangers | → | SouthamptonSOU | Undisclosed |
| 20 Jul 12 | P. Gazzaniga Paulo Gazzaniga |  GillinghamGIL | → | SouthamptonSOU | Undisclosed |
| 20 Jul 12 | T. Forecast Tommy Forecast | SouthamptonSOU | → | GillinghamGIL | Loan |
| 01 Jul 12 | L. Holmes Lee Holmes | SouthamptonSOU | → |  Preston North EndPNE | Free |
| 01 Jul 12 | A. Martin Aaron Martin | SouthamptonSOU | → | Crystal PalaceCRY | Loan |
| 20 Jun 12 | R. Doble Ryan Doble | SouthamptonSOU | → |  Shrewsbury TownSHR | Free |
| 15 Jun 12 | B. Bialkowski Bartosz Bialkowski | SouthamptonSOU | → |  Notts CountyNOTT | Free |
| 10 Jun 12 | J. Rodriguez Jay Rodriguez |  BurnleyBUR | → | SouthamptonSOU | Undisclosed |
| 21 May 12 | H. Dean Harlee Dean | SouthamptonSOU | → |  BrentfordBRE | Free |
| 15 Mar 12 | S. Hoskins Sam Hoskins | SouthamptonSOU | → |  Rotherham UnitedROT | Loan |
| 14 Mar 12 | L. Holmes Lee Holmes | SouthamptonSOU | → |  Swindon TownSWI | Loan |
| 23 Feb 12 | B. Reeves Ben Reeves | SouthamptonSOU | → |  Dagenham & RedbridgeD&R | Loan |
| 14 Feb 12 | L. Holmes Lee Holmes | SouthamptonSOU | → |  Oxford UnitedOXF | Loan |
| 09 Feb 12 | R. Dickson Ryan Dickson | SouthamptonSOU | → |  Leyton OrientLEY | Loan |
| 30 Jan 12 | B. Sharp Billy Sharp |  Doncaster RoversDON | → | SouthamptonSOU | Undisclosed |
| 27 Jan 12 | J. Forte Jonathan Forte | SouthamptonSOU | → | Notts CountyNOTT | Loan |
| 25 Jan 12 | T. Lee Tadanari Lee |  Sanfrecce HiroshimaSAN | → | SouthamptonSOU | Free |
| 17 Jan 12 | R. Doble Ryan Doble | SouthamptonSOU | → |  BuryBURY | Loan |
| 16 Jan 12 | I. Falque Iago Falque |  Tottenham HotspurTOT | → | SouthamptonSOU | Loan |
| 16 Jan 12 | I. Falque Iago Falque | Tottenham HotspurTOT | → | SouthamptonSOU | Loan |
| 06 Jan 12 | R. Dickson Ryan Dickson | SouthamptonSOU | → |  Yeovil TownYEO | Loan |