| 24 Oct 15 | L. Isgrove Lloyd Isgrove |  SouthamptonSOU | → |  BarnsleyBAR | Loan |
| 13 Oct 15 | J. McCarthy Jason McCarthy | SouthamptonSOU | → |  Wycombe WanderersWYC | Loan |
| 01 Sept 15 | V. van Dijk Virgil van Dijk |  CelticCEL | → | SouthamptonSOU | Undisclosed |
| 01 Sept 15 | V. van Dijk Virgil van Dijk | CelticCEL | → | SouthamptonSOU | Undisclosed |
| 31 Aug 15 | Emmanuel Mayuka | SouthamptonSOU | → |  MetzMETZ | Undisclosed |
| 12 Aug 15 | O. Romeu Oriol Romeu |  ChelseaCHE | → | SouthamptonSOU | Undisclosed |
| 03 Aug 15 | J. Turnbull Jordan Turnbull | SouthamptonSOU | → |  Swindon TownSWI | Loan |
| 31 Jul 15 | J. Stephens Jack Stephens | SouthamptonSOU | → |  MiddlesbroughMID | Loan |
| 31 Jul 15 | J. Stephens Jack Stephens | SouthamptonSOU | → | MiddlesbroughMID | Loan |
| 29 Jul 15 | S. Gallagher Sam Gallagher | SouthamptonSOU | → |  Milton Keynes DonsMKD | Loan |
| 29 Jul 15 | S. Caulker Steven Caulker |  Queens Park RangersQPR | → | SouthamptonSOU | Loan |
| 29 Jul 15 | S. Gallagher Sam Gallagher | SouthamptonSOU | → | Milton Keynes DonsMKD | Loan |
| 29 Jul 15 | S. Caulker Steven Caulker | Queens Park RangersQPR | → | SouthamptonSOU | Loan |
| 15 Jul 15 | J. Clasie Jordy Clasie |  Feyenoord RotterdamFEY | → | SouthamptonSOU | Undisclosed |
| 15 Jul 15 | J. Clasie Jordy Clasie | Feyenoord RotterdamFEY | → | SouthamptonSOU | Undisclosed |
| 13 Jul 15 | M. Schneiderlin Morgan Schneiderlin | SouthamptonSOU | → |  Manchester UnitedMAN | Undisclosed |
| 07 Jul 15 | C. Martina Cuco Martina |  FC TwenteTWE | → | SouthamptonSOU | Undisclosed |
| 07 Jul 15 | C. Martina Cuco Martina | FC TwenteTWE | → | SouthamptonSOU | Undisclosed |
| 01 Jul 15 | A. Boruc Artur Boruc | SouthamptonSOU | → |  AFC BournemouthBOU | Free |
| 01 Jul 15 | C. Soares Cédric Soares |  Sporting CPSCP | → | SouthamptonSOU | Undisclosed |
| 01 Jul 15 | N. Clyne Nathaniel Clyne | SouthamptonSOU | → |  LiverpoolLIV | Undisclosed |
| 01 Jul 15 | Juanmi |  MálagaMCF | → | SouthamptonSOU | Undisclosed |
| 01 Jul 15 | Juanmi | MálagaMCF | → | SouthamptonSOU | Undisclosed |
| 01 Jul 15 | M. Stekelenburg Maarten Stekelenburg |  FulhamFUL | → | SouthamptonSOU | Loan |
| 01 Jul 15 | M. Stekelenburg Maarten Stekelenburg | FulhamFUL | → | SouthamptonSOU | Loan |
| 01 Jul 15 | C. Cropper Cody Cropper | SouthamptonSOU | → | Milton Keynes DonsMKD | Free |
| 01 Jul 15 | A. Boruc Artur Boruc | SouthamptonSOU | → | AFC BournemouthBOU | Free |
| 01 Jul 15 | C. Cropper Cody Cropper | SouthamptonSOU | → | Milton Keynes DonsMKD | Free |
| 18 Mar 15 | L. Isgrove Lloyd Isgrove | SouthamptonSOU | → |  Sheffield WednesdaySHW | Loan |
| 18 Mar 15 | L. Isgrove Lloyd Isgrove | SouthamptonSOU | → | Sheffield WednesdaySHW | Loan |
| 12 Feb 15 | P. Osvaldo Pablo Osvaldo | SouthamptonSOU | → |  Boca JuniorsCABJ | Loan |
| 12 Feb 15 | P. Osvaldo Pablo Osvaldo | SouthamptonSOU | → | Boca JuniorsCABJ | Loan |
| 02 Feb 15 | R. Bertrand Ryan Bertrand | ChelseaCHE | → | SouthamptonSOU | Undisclosed |
| 02 Feb 15 | F. Djuricic Filip Djuricic |  BenficaBEN | → | SouthamptonSOU | Loan |
| 30 Jan 15 | J. Cork Jack Cork | SouthamptonSOU | → |  Swansea CitySWA | Undisclosed |
| 26 Jan 15 | J. Hooiveld Jos Hooiveld | SouthamptonSOU | → |  MillwallMIL | Loan |
| 26 Jan 15 | J. Hooiveld Jos Hooiveld | SouthamptonSOU | → | MillwallMIL | Loan |
| 03 Jan 15 | E. Elia Eljero Elia |  Werder BremenWER | → | SouthamptonSOU | Loan |
| 03 Jan 15 | E. Elia Eljero Elia | Werder BremenWER | → | SouthamptonSOU | Loan |