| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White |  Wolverhampton WanderersWOL | → |  Sheffield UnitedSHU | Loan |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk | Wolverhampton WanderersWOL | → |  Fortuna SittardFOR | Loan |
| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White | Wolverhampton WanderersWOL | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | C. Ronan Connor Ronan | Wolverhampton WanderersWOL | → |  St MirrenSTM | Loan |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk | Wolverhampton WanderersWOL | → | Fortuna SittardFOR | Loan |
| 31 Aug 21 | C. Ronan Connor Ronan | Wolverhampton WanderersWOL | → | St MirrenSTM | Loan |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan |  RB LeipzigRBL | → | Wolverhampton WanderersWOL | Loan |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → | Wolverhampton WanderersWOL | Loan |
| 24 Aug 21 | A. Samuels Austin Samuels | Wolverhampton WanderersWOL | → |  AberdeenABER | Loan |
| 24 Aug 21 | A. Samuels Austin Samuels | Wolverhampton WanderersWOL | → | AberdeenABER | Loan |
| 20 Aug 21 | O. Otasowie Owen Otasowie | Wolverhampton WanderersWOL | → |  Club BruggeBRUG | Undisclosed |
| 20 Aug 21 | R. Mir Rafa Mir | Wolverhampton WanderersWOL | → |  SevillaSEV | Undisclosed |
| 20 Aug 21 | R. Mir Rafa Mir | Wolverhampton WanderersWOL | → | SevillaSEV | Undisclosed |
| 13 Aug 21 | P. Cutrone Patrick Cutrone | Wolverhampton WanderersWOL | → |  EmpoliEMP | Loan |
| 13 Aug 21 | P. Cutrone Patrick Cutrone | Wolverhampton WanderersWOL | → | EmpoliEMP | Loan |
| 05 Aug 21 | T. Perry Taylor Perry | Wolverhampton WanderersWOL | → |  Cheltenham TownCHL | Loan |
| 02 Aug 21 | T. Corbeanu Theo Corbeanu | Wolverhampton WanderersWOL | → |  Sheffield WednesdaySHW | Loan |
| 30 Jul 21 | R. Dadashov Renat Dadashov | Wolverhampton WanderersWOL | → |  TondelaTON | Loan |
| 26 Jul 21 | M. Sarkic Matija Sarkic | Wolverhampton WanderersWOL | → |  Birmingham CityBIR | Loan |
| 26 Jul 21 | M. Sarkic Matija Sarkic | Wolverhampton WanderersWOL | → | Birmingham CityBIR | Loan |
| 19 Jul 21 | D. Sanderson Dion Sanderson | Wolverhampton WanderersWOL | → | Birmingham CityBIR | Loan |
| 19 Jul 21 | D. Sanderson Dion Sanderson | Wolverhampton WanderersWOL | → | Birmingham CityBIR | Loan |
| 17 Jul 21 | B. Bolla Bendeguz Bolla | Wolverhampton WanderersWOL | → |  GrasshoppersGCZ | Loan |
| 17 Jul 21 | B. Bolla Bendeguz Bolla | FXXFehervarFehervar | → | Wolverhampton WanderersWOL | Undisclosed |
| 16 Jul 21 | L. Campana Leonardo Campana | Wolverhampton WanderersWOL | → | GrasshoppersGCZ | Loan |
| 15 Jul 21 | J. Sá José Sá |  OlympiakosOLY | → | Wolverhampton WanderersWOL | Undisclosed |
| 13 Jul 21 | R. Giles Ryan John Giles | Wolverhampton WanderersWOL | → |  Cardiff CityCAR | Loan |
| 13 Jul 21 | R. Giles Ryan John Giles | Wolverhampton WanderersWOL | → | Cardiff CityCAR | Loan |
| 13 Jul 21 | R. Patrício Rui Patrício | Wolverhampton WanderersWOL | → |  AS RomaROMA | 11500000 |
| 13 Jul 21 | R. Patrício Rui Patrício | Wolverhampton WanderersWOL | → | AS RomaROMA | 11500000 |
| 10 Jul 21 | R. Aït-Nouri Rayan Aït-Nouri |  AngersANG | → | Wolverhampton WanderersWOL | Undisclosed |
| 10 Jul 21 | R. Aït-Nouri Rayan Aït-Nouri | AngersANG | → | Wolverhampton WanderersWOL | Undisclosed |
| 09 Jul 21 | R. Vinagre Ruben Vinagre | Wolverhampton WanderersWOL | → |  Sporting CPSCP | Loan |
| 04 Jul 21 | F. Trincão Francisco Trincão |  BarcelonaBAR | → | Wolverhampton WanderersWOL | Loan |
| 04 Jul 21 | F. Trincão Francisco Trincão | BarcelonaBAR | → | Wolverhampton WanderersWOL | Loan |
| 01 Jul 21 | Y. Mosquera Yerson Mosquera |  Atlético NacionalNAL | → | Wolverhampton WanderersWOL | Undisclosed |
| 01 Feb 21 | L. Matheson Luke Matheson | Wolverhampton WanderersWOL | → |  Ipswich TownIPS | Loan |
| 01 Feb 21 | R. Miranda Roderick Miranda | Wolverhampton WanderersWOL | → |  Gazisehir GaziantepGAZ | Free |
| 01 Feb 21 | T. Taylor Terry Taylor | Wolverhampton WanderersWOL | → |  Burton AlbionBRT | Undisclosed |
| 01 Feb 21 | M. Shabani Meritan Shabani | Wolverhampton WanderersWOL | → |  VVV-VenloVVV | Loan |
| 01 Feb 21 | M. Shabani Meritan Shabani | Wolverhampton WanderersWOL | → | VVV-VenloVVV | Loan |
| 01 Feb 21 | J. Pardington James Pardington | Wolverhampton WanderersWOL | → |  Mansfield TownMAN | Loan |
| 31 Jan 21 | P. Cutrone Patrick Cutrone | Wolverhampton WanderersWOL | → |  ValenciaVAL | Loan |
| 31 Jan 21 | P. Cutrone Patrick Cutrone | Wolverhampton WanderersWOL | → | ValenciaVAL | Loan |
| 25 Jan 21 | R. Giles Ryan John Giles | Wolverhampton WanderersWOL | → |  Rotherham UnitedROT | Loan |
| 25 Jan 21 | R. Giles Ryan John Giles | Wolverhampton WanderersWOL | → | Rotherham UnitedROT | Loan |
| 23 Jan 21 | Willian José |  Real SociedadRSO | → | Wolverhampton WanderersWOL | Loan |
| 23 Jan 21 | Willian José | Real SociedadRSO | → | Wolverhampton WanderersWOL | Loan |
| 18 Jan 21 | N. Ennis Niall Ennis | Wolverhampton WanderersWOL | → |  Plymouth ArgylePLY | Undisclosed |
| 11 Jan 21 | O. Buur Oskar Buur | Wolverhampton WanderersWOL | → | GXXGrasshopperGrasshopper | Loan |