| 31 Aug 21 | M. Ihattaren Mohamed Ihattaren | PSV EindhovenPSV | → | JuventusJUV | Undisclosed |
| 31 Aug 21 | M. Ihattaren Mohamed Ihattaren | PSV EindhovenPSV | → | JuventusJUV | Undisclosed |
| 27 Aug 21 | S. Colyn Simon Colyn | Vancouver WhitecapsVAN | → | PSV EindhovenPSV | Loan |
| 27 Aug 21 | S. Colyn Simon Colyn | Vancouver WhitecapsVAN | → | PSV EindhovenPSV | Loan |
| 26 Aug 21 | N. Markelo Nathangelo Markelo | EvertonEVE | → | PSV EindhovenPSV | Undisclosed |
| 26 Aug 21 | N. Markelo Nathangelo Markelo | EvertonEVE | → | PSV EindhovenPSV | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries | PSV EindhovenPSV | → | InternazionaleINT | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries | PSV EindhovenPSV | → | InternazionaleINT | Undisclosed |
| 10 Aug 21 | D. Sealy Dante Sealy | FC DallasDAL | → | PSV EindhovenPSV | Loan |
| 10 Aug 21 | D. Sealy Dante Sealy | FC DallasDAL | → | PSV EindhovenPSV | Loan |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 01 Jul 21 | D. Propper Davy Propper | Brighton & Hove AlbionBHA | → | PSV EindhovenPSV | Undisclosed |
| 01 Jul 21 | M. van Ginkel Marco van Ginkel | ChelseaCHE | → | PSV EindhovenPSV | Free |
| 01 Jul 21 | D. Propper Davy Propper | Brighton & Hove AlbionBHA | → | PSV EindhovenPSV | Undisclosed |
| 01 Jul 21 | M. van Ginkel Marco van Ginkel | ChelseaCHE | → | PSV EindhovenPSV | Free |
| 22 Mar 21 | C. Gloster Chris Gloster | PSV EindhovenPSV | → | New York City FCNYC | Allocation |
| 22 Mar 21 | C. Gloster Chris Gloster | PSV EindhovenPSV | → | New York City FCNYC | Allocation |