| 31 Aug 21 | Y. Herrera Yangel Herrera |  Manchester CityMNC | → |  EspanyolESP | Loan |
| 31 Aug 21 | T. Doyle Tommy Doyle | Manchester CityMNC | → |  Hamburg SVHSV | Loan |
| 31 Aug 21 | C. Gomes Claudio Gomes | Manchester CityMNC | → |  BarnsleyBAR | Loan |
| 31 Aug 21 | Y. Herrera Yangel Herrera | Manchester CityMNC | → | EspanyolESP | Loan |
| 31 Aug 21 | P. Sandler Philippe Sandler | Manchester CityMNC | → |  TroyesTRY | Loan |
| 31 Aug 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | E. Palmer-Brown Erik Palmer-Brown | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | C. Gomes Claudio Gomes | Manchester CityMNC | → | BarnsleyBAR | Loan |
| 31 Aug 21 | P. Sandler Philippe Sandler | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | E. Palmer-Brown Erik Palmer-Brown | Manchester CityMNC | → | TroyesTRY | Loan |
| 23 Aug 21 | Morgan Rogers | Manchester CityMNC | → |  AFC BournemouthBOU | Loan |
| 23 Aug 21 | Morgan Rogers | Manchester CityMNC | → | AFC BournemouthBOU | Loan |
| 22 Aug 21 | Y. Couto Yan Couto | Manchester CityMNC | → |  BragaBRAG | Loan |
| 20 Aug 21 | D. Arzani Daniel Arzani | Manchester CityMNC | → | LSXLommel SKLommel SK | Loan |
| 20 Aug 21 | K. Itakura Kou Itakura | Manchester CityMNC | → |  Schalke 04SCHA | Loan |
| 16 Aug 21 | B. Knight Ben Knight | Manchester CityMNC | → |  Crewe AlexandraCREW | Loan |
| 12 Aug 21 | I. Ilić Ivan Ilić | Manchester CityMNC | → |  Hellas VeronaVER | Undisclosed |
| 12 Aug 21 | I. Ilić Ivan Ilić | Manchester CityMNC | → | Hellas VeronaVER | Undisclosed |
| 06 Aug 21 | M. Smith Matthew Smith | Manchester CityMNC | → |  Hull CityHUL | Loan |
| 06 Aug 21 | M. Smith Matt Smith | Manchester CityMNC | → | Hull CityHUL | Loan |
| 05 Aug 21 | J. Grealish Jack Grealish |  Aston VillaAVL | → | Manchester CityMNC | 100000000 |
| 05 Aug 21 | A. Muric Aro Muric | Manchester CityMNC | → |  Adana DemirsporADD | Loan |
| 02 Aug 21 | R. Meshino Ryotaro Meshino | Manchester CityMNC | → |  EstorilEST | Loan |
| 20 Jul 21 | S. Carson Scott Carson | XXX | → | Manchester CityMNC | Free |
| 17 Jul 21 | L. Nmecha Lukas Nmecha | Manchester CityMNC | → |  VfL WolfsburgWOB | Undisclosed |
| 17 Jul 21 | L. Nmecha Lukas Nmecha | Manchester CityMNC | → | VfL WolfsburgWOB | Undisclosed |
| 16 Jul 21 | C. Doyle Callum Doyle | Manchester CityMNC | → |  SunderlandSUN | Loan |
| 09 Jul 21 | F. Stevanovic Filip Stevanovic | Manchester CityMNC | → |  HeerenveenHEE | Loan |
| 09 Jul 21 | F. Stevanovic Filip Stevanovic | Manchester CityMNC | → | HeerenveenHEE | Loan |
| 05 Jul 21 | A. Robertson Alex Robertson | Manchester CityMNC | → |  Ross CountyROSS | Loan |
| 05 Jul 21 | A. Robertson Alex Robertson | Manchester CityMNC | → | Ross CountyROSS | Loan |
| 02 Jul 21 | L. Fiorini Lewis Fiorini | Manchester CityMNC | → |  Lincoln CityLCN | Loan |
| 02 Jul 21 | J. Harrison Jack Harrison | Manchester CityMNC | → |  Leeds UnitedLEE | Undisclosed |
| 01 Jul 21 | Kayky Chagas |  FluminenseFLU | → | Manchester CityMNC | Undisclosed |
| 01 Jul 21 | Angeliño | Manchester CityMNC | → |  RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | Kayky Chagas | FluminenseFLU | → | Manchester CityMNC | Undisclosed |
| 01 Jul 21 | D. Sarmiento Dario Sarmiento |  Estudiantes de La PlataEST | → | Manchester CityMNC | Undisclosed |
| 01 Jul 21 | S. Agüero Sergio Agüero | Manchester CityMNC | → |  BarcelonaBAR | Free |
| 01 Jul 21 | E. García Eric García | Manchester CityMNC | → | BarcelonaBAR | Free |
| 01 Jul 21 | G. Bazunu Gavin Bazunu | Manchester CityMNC | → |  PortsmouthPOR | Loan |
| 01 Jul 21 | T. Harwood-Bellis Taylor Harwood-Bellis | Manchester CityMNC | → |  AnderlechtAND | Loan |
| 01 Jul 21 | I. Kabore Issa Kabore | Manchester CityMNC | → | TroyesTRY | Loan |
| 01 Jul 21 | M. Moreno Marlos Moreno | Manchester CityMNC | → |  KV KortrijkKVK | Loan |
| 01 Jul 21 | J. Trafford James Trafford | Manchester CityMNC | → |  Accrington StanleyACCR | Loan |
| 01 Jul 21 | S. Agüero Sergio Agüero | Manchester CityMNC | → | BarcelonaBAR | Free |
| 01 Jul 21 | E. García Eric García | Manchester CityMNC | → | BarcelonaBAR | Free |
| 01 Jul 21 | Angeliño | Manchester CityMNC | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | I. Kabore Issa Kabore | Manchester CityMNC | → | TroyesTRY | Loan |
| 01 Jul 21 | D. Sarmiento Dario Sarmiento | Estudiantes de La PlataEST | → | Manchester CityMNC | Undisclosed |
| 10 Feb 21 | Joe Hodge | Manchester CityMNC | → |  Derry CityDCFC | Loan |
| 01 Feb 21 | A. Muric Aro Muric | Manchester CityMNC | → |  Willem IIWIL | Loan |
| 01 Feb 21 | T. Harwood-Bellis Taylor Harwood-Bellis | Manchester CityMNC | → |  Blackburn RoversBLK | Loan |
| 01 Feb 21 | J. Braaf Jayden Braaf | Manchester CityMNC | → |  UdineseUDN | Loan |
| 01 Feb 21 | A. Muric Aro Muric | Manchester CityMNC | → | Willem IIWIL | Loan |
| 01 Feb 21 | K. Simmonds Keyendrah Simmonds | Manchester CityMNC | → |  Birmingham CityBIR | Undisclosed |
| 01 Feb 21 | J. Braaf Jayden Braaf | Manchester CityMNC | → | UdineseUDN | Loan |
| 01 Feb 21 | Diego Rosa |  GrêmioGRE | → | Manchester CityMNC | Undisclosed |
| 01 Feb 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → |  Derby CountyDER | Loan |
| 01 Feb 21 | Diego Rosa | GrêmioGRE | → | Manchester CityMNC | Undisclosed |
| 01 Feb 21 | Diego Rosa | Manchester CityMNC | → | LSXLommel SKLommel SK | Loan |
| 01 Feb 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → | Derby CountyDER | Loan |
| 01 Feb 21 | K. Simmonds Keyendrah Simmonds | Manchester CityMNC | → | Birmingham CityBIR | Undisclosed |
| 01 Feb 21 | T. Harwood-Bellis Taylor Harwood-Bellis | Manchester CityMNC | → | Blackburn RoversBLK | Loan |
| 26 Jan 21 | A. Palaversa Ante Palaversa | Manchester CityMNC | → | KV KortrijkKVK | Loan |
| 26 Jan 21 | D. Arzani Daniel Arzani | Manchester CityMNC | → |  AGF AarhusAGF | Loan |
| 25 Jan 21 | N. Ogbeta Nathanael Ogbeta | Manchester CityMNC | → |  Shrewsbury TownSHR | Undisclosed |
| 25 Jan 21 | T. Scott Tom Scott | Manchester CityMNC | → |  Port ValeVALE | Undisclosed |
| 11 Jan 21 | F. Stevanovic Filip Stevanovic | Manchester CityMNC | → | PBXPartizan BelgradePartizan Belgrade | Loan |
| 04 Jan 21 | M. Rogers Morgan Rogers | Manchester CityMNC | → | Lincoln CityLCN | Loan |
| 02 Jan 21 | F. Stevanovic Filip Stevanovic | PBXPartizan BelgradePartizan Belgrade | → | Manchester CityMNC | Undisclosed |