| 27 Nov 08 | R. Zieler Ron-Robert Zieler |  Manchester UnitedMAN | → |  Northampton TownNHT | Loan |
| 01 Sept 08 | D. Berbatov Dimitar Berbatov |  Tottenham HotspurTOT | → | Manchester UnitedMAN | 30750000 |
| 01 Sept 08 | L. Saha Louis Saha | Manchester UnitedMAN | → |  EvertonEVE | Undisclosed |
| 01 Sept 08 | F. Campbell Fraizer Campbell | Manchester UnitedMAN | → | Tottenham HotspurTOT | Loan |
| 20 Aug 08 | M. Silvestre Mikael Silvestre | Manchester UnitedMAN | → |  ArsenalARS | Undisclosed |
| 13 Aug 08 | L. Martin Lee Martin | Manchester UnitedMAN | → |  Nottingham ForestFOR | Loan |
| 13 Aug 08 | L. Martin Lee Martin | Manchester UnitedMAN | → | Nottingham ForestFOR | Loan |
| 08 Aug 08 | C. Cathcart Craig Cathcart | Manchester UnitedMAN | → |  Plymouth ArgylePLY | Loan |
| 08 Aug 08 | C. Cathcart Craig Cathcart | Manchester UnitedMAN | → | Plymouth ArgylePLY | Loan |
| 04 Aug 08 | D. Simpson Danny Simpson | Manchester UnitedMAN | → |  Blackburn RoversBLK | Loan |
| 29 Jul 08 | C. Eagles Chris Eagles | Manchester UnitedMAN | → |  BurnleyBUR | Undisclosed |
| 29 Jul 08 | C. Eagles Chris Eagles | Manchester UnitedMAN | → | BurnleyBUR | Undisclosed |
| 22 Jul 08 | F. Brandy Febian Brandy | Manchester UnitedMAN | → |  Swansea CitySWA | Loan |
| 22 Jul 08 | F. Brandy Febian Brandy | Manchester UnitedMAN | → | Swansea CitySWA | Loan |
| 27 May 08 | G. Piqué Gerard Piqué | Manchester UnitedMAN | → |  BarcelonaBAR | Undisclosed |
| 27 May 08 | G. Piqué Gerard Piqué | Manchester UnitedMAN | → | BarcelonaBAR | Undisclosed |
| 21 May 08 | K. Lee Kieran Lee | Manchester UnitedMAN | → |  Oldham AthleticOLD | Free |
| 27 Mar 08 | M. Barnes Michael Barnes | Manchester UnitedMAN | → |  Shrewsbury TownSHR | Loan |
| 21 Mar 08 | D. Simpson Danny Simpson | Manchester UnitedMAN | → |  Ipswich TownIPS | Loan |
| 21 Mar 08 | D. Simpson Danny Simpson | Manchester UnitedMAN | → | Ipswich TownIPS | Loan |
| 22 Jan 08 | P. Bardsley Phil Bardsley | Manchester UnitedMAN | → |  SunderlandSUN | Undisclosed |
| 18 Jan 08 | R. Shawcross Ryan Shawcross | Manchester UnitedMAN | → |  Stoke CitySTK | 1000000 |
| 17 Jan 08 | F. Brandy Febian Brandy | Manchester UnitedMAN | → | Swansea CitySWA | Loan |
| 17 Jan 08 | F. Brandy Febian Brandy | Manchester UnitedMAN | → | Swansea CitySWA | Loan |
| 10 Jan 08 | L. Martin Lee Martin | Manchester UnitedMAN | → |  Sheffield UnitedSHU | Loan |
| 10 Jan 08 | L. Martin Lee Martin | Manchester UnitedMAN | → | Sheffield UnitedSHU | Loan |
| 04 Jan 08 | J. Evans Jonny Evans | Manchester UnitedMAN | → | SunderlandSUN | Loan |
| 03 Jan 08 | Michael Barnes | Manchester UnitedMAN | → |  ChesterfieldCHES | Loan |
| 01 Jan 08 | A. Eckersley Adam Eckersley | Manchester UnitedMAN | → |  Port ValeVALE | Free |
| 01 Jan 08 | Manucho | PALPetro Atletico LuandaPetro Atletico Luanda | → | Manchester UnitedMAN | Undisclosed |