| 31 Aug 21 | C. Ronaldo Cristiano Ronaldo |  JuventusJUV | → |  Manchester UnitedMAN | 15000000 |
| 31 Aug 21 | C. Ronaldo Cristiano Ronaldo | JuventusJUV | → | Manchester UnitedMAN | 15000000 |
| 31 Aug 21 | D. James Daniel James | Manchester UnitedMAN | → |  Leeds UnitedLEE | Undisclosed |
| 23 Aug 21 | B. Williams Brandon Williams | Manchester UnitedMAN | → |  Norwich CityNOR | Loan |
| 22 Aug 21 | J. Garner James Garner | Manchester UnitedMAN | → |  Nottingham ForestFOR | Loan |
| 22 Aug 21 | J. Garner James Garner | Manchester UnitedMAN | → | Nottingham ForestFOR | Loan |
| 20 Aug 21 | D. Levitt Dylan Levitt | Manchester UnitedMAN | → |  Dundee UnitedDUN | Loan |
| 20 Aug 21 | D. Levitt Dylan Levitt | Manchester UnitedMAN | → | Dundee UnitedDUN | Loan |
| 20 Aug 21 | A. Pereira Andrea Pereira | Manchester UnitedMAN | → |  FlamengoFLA | Loan |
| 20 Aug 21 | A. Pereira Andrea Pereira | Manchester UnitedMAN | → | FlamengoFLA | Loan |
| 16 Aug 21 | E. Laird Ethan Laird | Manchester UnitedMAN | → |  Swansea CitySWA | Loan |
| 16 Aug 21 | E. Laird Ethan Laird | Manchester UnitedMAN | → | Swansea CitySWA | Loan |
| 14 Aug 21 | R. Varane Raphaël Varane |  Real MadridMAD | → | Manchester UnitedMAN | Undisclosed |
| 14 Aug 21 | R. Varane Raphaël Varane | Real MadridMAD | → | Manchester UnitedMAN | Undisclosed |
| 13 Aug 21 | E. Galbraith Ethan Galbraith | Manchester UnitedMAN | → |  Doncaster RoversDON | Loan |
| 08 Aug 21 | A. Tuanzebe Axel Tuanzebe | Manchester UnitedMAN | → |  Aston VillaAVL | Loan |
| 05 Aug 21 | F. Pellistri Facundo Pellistri | Manchester UnitedMAN | → |  AlavésALV | Loan |
| 05 Aug 21 | F. Pellistri Facundo Pellistri | Manchester UnitedMAN | → | AlavésALV | Loan |
| 30 Jul 21 | D. Bernard Di'Shon Bernard | Manchester UnitedMAN | → |  Hull CityHUL | Loan |
| 30 Jul 21 | D. Bernard Di'Shon Bernard | Manchester UnitedMAN | → | Hull CityHUL | Loan |
| 26 Jul 21 | T. Chong Tahith Chong | Manchester UnitedMAN | → |  Birmingham CityBIR | Loan |
| 26 Jul 21 | T. Chong Tahith Chong | Manchester UnitedMAN | → | Birmingham CityBIR | Loan |
| 23 Jul 21 | J. Sancho Jadon Sancho |  Borussia DortmundDOR | → | Manchester UnitedMAN | Undisclosed |
| 23 Jul 21 | J. Sancho Jadon Sancho | Borussia DortmundDOR | → | Manchester UnitedMAN | Undisclosed |
| 02 Jul 21 | T. Heaton Tom Heaton | Aston VillaAVL | → | Manchester UnitedMAN | Free |
| 02 Jul 21 | R. Devine Reece Devine | Manchester UnitedMAN | → |  St JohnstoneSTJO | Loan |
| 02 Jul 21 | R. Devine Reece Devine | Manchester UnitedMAN | → | St JohnstoneSTJO | Loan |
| 01 Jul 21 | N. Bishop Nathan Bishop | Manchester UnitedMAN | → |  Mansfield TownMAN | Loan |
| 02 Feb 21 | M. Rojo Marcos Rojo | Manchester UnitedMAN | → |  Boca JuniorsCABJ | Undisclosed |
| 02 Feb 21 | M. Rojo Marcos Rojo | Manchester UnitedMAN | → | Boca JuniorsCABJ | Undisclosed |
| 01 Feb 21 | T. Mengi Teden Mengi | Manchester UnitedMAN | → |  Derby CountyDER | Loan |
| 01 Feb 21 | T. Mengi Teden Mengi | Manchester UnitedMAN | → | Derby CountyDER | Loan |
| 31 Jan 21 | F. Pellistri Facundo Pellistri | Manchester UnitedMAN | → | AlavésALV | Loan |
| 31 Jan 21 | F. Pellistri Facundo Pellistri | Manchester UnitedMAN | → | AlavésALV | Loan |
| 30 Jan 21 | J. Garner James Garner | Manchester UnitedMAN | → | Nottingham ForestFOR | Loan |
| 30 Jan 21 | J. Garner James Garner | Manchester UnitedMAN | → | Nottingham ForestFOR | Loan |
| 30 Jan 21 | T. Chong Tahith Chong | Manchester UnitedMAN | → |  Club BruggeBRUG | Loan |
| 29 Jan 21 | J. Lingard Jesse Lingard | Manchester UnitedMAN | → |  West Ham UnitedWHU | Loan |
| 13 Jan 21 | T. Fosu-Mensah Timothy Fosu-Mensah | Manchester UnitedMAN | → |  Bayer LeverkusenLEV | Undisclosed |
| 13 Jan 21 | T. Fosu-Mensah Timothy Fosu-Mensah | Manchester UnitedMAN | → | Bayer LeverkusenLEV | Undisclosed |
| 08 Jan 21 | E. Laird Ethan Laird | Manchester UnitedMAN | → |  Milton Keynes DonsMKD | Loan |
| 07 Jan 21 | A. Diallo Amad Diallo |  AtalantaATA | → | Manchester UnitedMAN | Undisclosed |
| 07 Jan 21 | A. Diallo Amad Diallo | AtalantaATA | → | Manchester UnitedMAN | Undisclosed |