| 25 Nov 10 | C. Stewart Cameron Stewart |  Manchester UnitedMAN | → |  Hull CityHUL | Loan |
| 25 Nov 10 | S. Wootton Scott Wootton | Manchester UnitedMAN | → |  Tranmere RoversTRN | Loan |
| 25 Nov 10 | C. Stewart Cameron Stewart | Manchester UnitedMAN | → | Hull CityHUL | Loan |
| 25 Nov 10 | J. King Joshua King | Manchester UnitedMAN | → |  Preston North EndPNE | Loan |
| 25 Nov 10 | J. King Joshua King | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 17 Nov 10 | R. de Laet Ritchie de Laet | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 17 Nov 10 | R. de Laet Ritchie de Laet | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 22 Oct 10 | C. Evans Corry Evans | Manchester UnitedMAN | → |  Carlisle UnitedCAR | Loan |
| 30 Sept 10 | S. Wootton Scott Wootton | Manchester UnitedMAN | → | Tranmere RoversTRN | Loan |
| 29 Sept 10 | R. Brown Reece Brown | Manchester UnitedMAN | → |  Bradford CityBRD | Loan |
| 29 Sept 10 | O. Gill Oliver Gill | Manchester UnitedMAN | → | Bradford CityBRD | Loan |
| 28 Sept 10 | C. Devlin Conor Devlin | Manchester UnitedMAN | → |  Hartlepool UnitedHAR | Loan |
| 25 Sept 10 | N. Ajose Nicky Ajose | Manchester UnitedMAN | → |  BuryBURY | Loan |
| 24 Sept 10 | R. de Laet Ritchie de Laet | Manchester UnitedMAN | → |  Sheffield UnitedSHU | Loan |
| 24 Sept 10 | R. de Laet Ritchie de Laet | Manchester UnitedMAN | → | Sheffield UnitedSHU | Loan |
| 16 Sept 10 | O. Norwood Oliver Norwood | Manchester UnitedMAN | → | Carlisle UnitedCAR | Loan |
| 31 Aug 10 | T. Cleverley Tom Cleverley | Manchester UnitedMAN | → |  Wigan AthleticWGA | Loan |
| 16 Aug 10 | Bebé |  GuimaraesGUI | → | Manchester UnitedMAN | Undisclosed |
| 12 Aug 10 | D. Welbeck Danny Welbeck | Manchester UnitedMAN | → |  SunderlandSUN | Loan |
| 11 Aug 10 | C. Cathcart Craig Cathcart | Manchester UnitedMAN | → |  BlackpoolBLP | Undisclosed |
| 07 Aug 10 | J. King Joshua King | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 07 Aug 10 | J. King Joshua King | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 06 Aug 10 | M. Diouf Mame Biram Diouf | Manchester UnitedMAN | → |  Blackburn RoversBLK | Loan |
| 06 Aug 10 | J. Chester James Chester | Manchester UnitedMAN | → | Carlisle UnitedCAR | Loan |
| 06 Aug 10 | T. Heaton Tom Heaton | Manchester UnitedMAN | → |  Cardiff CityCAR | Free |
| 06 Aug 10 | D. Drinkwater Danny Drinkwater | Manchester UnitedMAN | → | Cardiff CityCAR | Loan |
| 06 Aug 10 | D. Drinkwater Danny Drinkwater | Manchester UnitedMAN | → | Cardiff CityCAR | Loan |
| 06 Aug 10 | T. Heaton Tom Heaton | Manchester UnitedMAN | → | Cardiff CityCAR | Free |
| 30 Jul 10 | C. Stewart Cameron Stewart | Manchester UnitedMAN | → |  Yeovil TownYEO | Loan |
| 16 Jul 10 | D. Gray David Gray | Manchester UnitedMAN | → | Preston North EndPNE | Free |
| 16 Jul 10 | D. Gray David Gray | Manchester UnitedMAN | → | Preston North EndPNE | Free |
| 02 Jul 10 | M. James Matty James | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 02 Jul 10 | M. James Matty James | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 01 Jul 10 | J. Hernández Javier Hernández |  GuadalajaraGDL | → | Manchester UnitedMAN | Undisclosed |
| 01 Jul 10 | J. Hernández Javier Hernández | GuadalajaraGDL | → | Manchester UnitedMAN | Undisclosed |
| 01 Jul 10 | C. Smalling Chris Smalling |  FulhamFUL | → | Manchester UnitedMAN | Undisclosed |
| 01 Jul 10 | R. Zieler Ron-Robert Zieler | Manchester UnitedMAN | → |  Hannover 96HAN | Free |
| 01 Jul 10 | R. Zieler Ron-Robert Zieler | Manchester UnitedMAN | → | Hannover 96HAN | Free |
| 15 Jun 10 | Z. Tosic Zoran Tosic | Manchester UnitedMAN | → |  CSKA MoscowCSK | Undisclosed |
| 19 May 10 | B. Foster Ben Foster | Manchester UnitedMAN | → |  Birmingham CityBIR | Undisclosed |
| 12 Feb 10 | T. Heaton Tom Heaton | Manchester UnitedMAN | → |  Wycombe WanderersWYC | Loan |
| 09 Feb 10 | M. James Matty James | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 09 Feb 10 | M. James Matty James | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 01 Feb 10 | S. Hewson Sam Hewson | Manchester UnitedMAN | → | BuryBURY | Loan |
| 27 Jan 10 | Z. Tosic Zoran Tosic | Manchester UnitedMAN | → |  FC CologneCOL | Loan |
| 27 Jan 10 | Z. Tosic Zoran Tosic | Manchester UnitedMAN | → | FC CologneCOL | Loan |
| 25 Jan 10 | D. Welbeck Danny Welbeck | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 25 Jan 10 | D. Welbeck Danny Welbeck | Manchester UnitedMAN | → | Preston North EndPNE | Loan |
| 20 Jan 10 | D. Simpson Danny Simpson | Manchester UnitedMAN | → |  Newcastle UnitedNEW | Undisclosed |
| 20 Jan 10 | D. Simpson Danny Simpson | Manchester UnitedMAN | → | Newcastle UnitedNEW | Undisclosed |