| 01 Sept 22 | J. Garner James Garner |  Manchester UnitedMAN | → |  EvertonEVE | Undisclosed |
| 01 Sept 22 | T. Chong Tahith Chong | Manchester UnitedMAN | → |  Birmingham CityBIR | Undisclosed |
| 01 Sept 22 | E. Galbraith Ethan Galbraith | Manchester UnitedMAN | → |  Salford CitySAL | Loan |
| 01 Sept 22 | W. Fish William Fish | Manchester UnitedMAN | → |  HibernianHIBS | Loan |
| 01 Sept 22 | M. Dúbravka Martin Dúbravka |  Newcastle UnitedNEW | → | Manchester UnitedMAN | Loan |
| 01 Sept 22 | Antony |  Ajax AmsterdamAJA | → | Manchester UnitedMAN | 95000000 |
| 31 Aug 22 | A. Diallo Amad Diallo | Manchester UnitedMAN | → |  SunderlandSUN | Loan |
| 29 Aug 22 | H. Mejbri Hannibal Mejbri | Manchester UnitedMAN | → | Birmingham CityBIR | Loan |
| 24 Aug 22 | E. Bailly Eric Bailly | Manchester UnitedMAN | → |  MarseilleOLM | Loan |
| 22 Aug 22 | Casemiro |  Real MadridRMA | → | Manchester UnitedMAN | Undisclosed |
| 15 Aug 22 | E. Laird Ethan Laird | Manchester UnitedMAN | → |  Queens Park RangersQPR | Loan |
| 04 Aug 22 | A. Telles Alex Telles | Manchester UnitedMAN | → |  SevillaSEV | Loan |
| 27 Jul 22 | L. Martínez Lisandro Martínez | Ajax AmsterdamAJA | → | Manchester UnitedMAN | 57370000 |
| 26 Jul 22 | Á. Fernández Álvaro Fernández | Manchester UnitedMAN | → |  Preston North EndPNE | Loan |
| 21 Jul 22 | J. Lingard Jesse Lingard | Manchester UnitedMAN | → |  Nottingham ForestNFO | Free |
| 15 Jul 22 | C. Eriksen Christian Eriksen |  BrentfordBRE | → | Manchester UnitedMAN | Free |
| 11 Jul 22 | P. Pogba Paul Pogba | Manchester UnitedMAN | → |  JuventusJUV | Free |
| 11 Jul 22 | A. Pereira Andreas Pereira | Manchester UnitedMAN | → |  FulhamFUL | Undisclosed |
| 07 Jul 22 | D. Levitt Dylan Levitt | Manchester UnitedMAN | → |  Dundee UnitedDUN | Undisclosed |
| 07 Jul 22 | M. Svidersky Martin Svidersky | Manchester UnitedMAN | → |  AlmeríaALM | Free |
| 05 Jul 22 | T. Malacia Tyrell Malacia |  Feyenoord RotterdamFEY | → | Manchester UnitedMAN | Undisclosed |
| 02 Jul 22 | D. Henderson Dean Henderson | Manchester UnitedMAN | → | Nottingham ForestNFO | Loan |
| 01 Jul 22 | N. Matic Nemanja Matic | Manchester UnitedMAN | → |  AS RomaROMA | Free |
| 31 Jan 22 | M. Kovar Matej Kovar | Manchester UnitedMAN | → |  Burton AlbionBRT | Loan |
| 31 Jan 22 | D. van de Beek Donny van de Beek | Manchester UnitedMAN | → | EvertonEVE | Loan |
| 28 Jan 22 | R. Devine Reece Devine | Manchester UnitedMAN | → |  WalsallWAL | Loan |
| 27 Jan 22 | A. Diallo Amad Diallo | Manchester UnitedMAN | → |  RangersRAN | Loan |
| 25 Jan 22 | A. Martial Anthony Martial | Manchester UnitedMAN | → | SevillaSEV | Loan |
| 08 Jan 22 | A. Tuanzebe Axel Tuanzebe | Manchester UnitedMAN | → |  NapoliNAP | Loan |
| 06 Jan 22 | E. Laird Ethan Laird | Manchester UnitedMAN | → |  AFC BournemouthBOU | Loan |
| 04 Jan 22 | T. Mengi Teden Mengi | Manchester UnitedMAN | → | Birmingham CityBIR | Loan |