| 31 Aug 21 | R. Nelson Reiss Nelson |  ArsenalARS | → |  Feyenoord RotterdamFEY | Loan |
| 31 Aug 21 | M. Ihattaren Mohamed Ihattaren |  PSV EindhovenPSV | → |  JuventusJUV | Undisclosed |
| 31 Aug 21 | A. Musaba Anthony Musaba |  AS MonacoMON | → |  HeerenveenHEE | Loan |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk |  Wolverhampton WanderersWOL | → |  Fortuna SittardFOR | Loan |
| 31 Aug 21 | L. Magallán Lisandro Magallán |  Ajax AmsterdamAJA | → |  AnderlechtAND | Loan |
| 31 Aug 21 | M. Ihattaren Mohamed Ihattaren | PSV EindhovenPSV | → | JuventusJUV | Undisclosed |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk | Wolverhampton WanderersWOL | → | Fortuna SittardFOR | Loan |
| 31 Aug 21 | R. Nelson Reiss Nelson | ArsenalARS | → | Feyenoord RotterdamFEY | Loan |
| 31 Aug 21 | A. Musaba Anthony Musaba | AS MonacoMON | → | HeerenveenHEE | Loan |
| 28 Aug 21 | M. Daramy Mohamed Daramy |  FC CopenhagenCOP | → | Ajax AmsterdamAJA | Undisclosed |
| 27 Aug 21 | J. Ekkelenkamp Jurgen Ekkelenkamp | Ajax AmsterdamAJA | → |  Hertha BerlinHERT | Undisclosed |
| 27 Aug 21 | J. Ekkelenkamp Jurgen Ekkelenkamp | Ajax AmsterdamAJA | → | Hertha BerlinHERT | Undisclosed |
| 27 Aug 21 | S. Colyn Simon Colyn |  Vancouver WhitecapsVAN | → | PSV EindhovenPSV | Loan |
| 27 Aug 21 | S. Colyn Simon Colyn | Vancouver WhitecapsVAN | → | PSV EindhovenPSV | Loan |
| 26 Aug 21 | N. Markelo Nathangelo Markelo |  EvertonEVE | → | PSV EindhovenPSV | Undisclosed |
| 26 Aug 21 | N. Markelo Nathangelo Markelo | EvertonEVE | → | PSV EindhovenPSV | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries | PSV EindhovenPSV | → |  InternazionaleINT | Undisclosed |
| 14 Aug 21 | D. Dumfries Denzel Dumfries | PSV EindhovenPSV | → | InternazionaleINT | Undisclosed |
| 13 Aug 21 | R. Johansson Ryan Johansson |  SevillaSEV | → | Fortuna SittardFOR | Loan |
| 13 Aug 21 | R. Johansson Ryan Johansson | SevillaSEV | → | Fortuna SittardFOR | Loan |
| 10 Aug 21 | D. Sealy Dante Sealy |  FC DallasDAL | → | PSV EindhovenPSV | Loan |
| 10 Aug 21 | D. Sealy Dante Sealy | FC DallasDAL | → | PSV EindhovenPSV | Loan |
| 04 Aug 21 | M. Boadu Myron Boadu |  AZ AlkmaarAZ | → | AS MonacoMON | Undisclosed |
| 04 Aug 21 | M. Boadu Myron Boadu | AZ AlkmaarAZ | → | AS MonacoMON | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → |  Borussia DortmundDOR | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 17 Jul 21 | A. Jahanbakhsh Alireza Jahanbakhsh |  Brighton & Hove AlbionBHA | → | Feyenoord RotterdamFEY | Undisclosed |
| 17 Jul 21 | A. Jahanbakhsh Alireza Jahanbakhsh | Brighton & Hove AlbionBHA | → | Feyenoord RotterdamFEY | Undisclosed |
| 16 Jul 21 | K. Scherpen Kjell Scherpen | Ajax AmsterdamAJA | → | Brighton & Hove AlbionBHA | Undisclosed |
| 16 Jul 21 | S. Berghuis Steven Berghuis | Feyenoord RotterdamFEY | → | Ajax AmsterdamAJA | Undisclosed |
| 16 Jul 21 | K. Scherpen Kjell Scherpen | Ajax AmsterdamAJA | → | Brighton & Hove AlbionBHA | Undisclosed |
| 14 Jul 21 | N. Baden Frederiksen Nikolai Baden Frederiksen | JuventusJUV | → |  VitesseVIT | Undisclosed |
| 14 Jul 21 | N. Michelis Nikos Michelis |  AC MilanMIL | → |  Willem IIWIL | Loan |
| 14 Jul 21 | N. Baden Frederiksen Nikolai Baden Frederiksen | JuventusJUV | → | VitesseVIT | Undisclosed |
| 14 Jul 21 | N. Michelis Nikos Michelis | AC MilanMIL | → | Willem IIWIL | Loan |
| 11 Jul 21 | R. Yapi Romaric Yapi | Brighton & Hove AlbionBHA | → | VitesseVIT | Undisclosed |
| 11 Jul 21 | R. Yapi Romaric Yapi | Brighton & Hove AlbionBHA | → | VitesseVIT | Undisclosed |
| 09 Jul 21 | F. Stevanovic Filip Stevanovic |  Manchester CityMNC | → | HeerenveenHEE | Loan |
| 09 Jul 21 | F. Stevanovic Filip Stevanovic | Manchester CityMNC | → | HeerenveenHEE | Loan |
| 01 Jul 21 | N. Marsman Nick Marsman | Feyenoord RotterdamFEY | → |  Inter Miami CFMIA | Free |
| 01 Jul 21 | D. Propper Davy Propper | Brighton & Hove AlbionBHA | → | PSV EindhovenPSV | Undisclosed |
| 01 Jul 21 | M. van Ginkel Marco van Ginkel |  ChelseaCHE | → | PSV EindhovenPSV | Free |
| 01 Jul 21 | R. Marin Razvan Marin | Ajax AmsterdamAJA | → |  CagliariCAG | Undisclosed |
| 01 Jul 21 | B. Brobbey Brian Brobbey | Ajax AmsterdamAJA | → |  RB LeipzigRBL | Free |
| 01 Jul 21 | A. Zagre Arthur Zagre | AS MonacoMON | → |  FC UtrechtUTR | Loan |
| 01 Jul 21 | J. Gorter Jay Gorter |  Go Ahead EaglesGAE | → | Ajax AmsterdamAJA | Undisclosed |
| 01 Jul 21 | N. Lang Noa Lang | Ajax AmsterdamAJA | → |  Club BruggeBRUG | Undisclosed |
| 01 Jul 21 | R. Marin Razvan Marin | Ajax AmsterdamAJA | → | CagliariCAG | Undisclosed |
| 01 Jul 21 | D. Propper Davy Propper | Brighton & Hove AlbionBHA | → | PSV EindhovenPSV | Undisclosed |
| 01 Jul 21 | L. Traoré Lassina Traoré | Ajax AmsterdamAJA | → | SDXShakhtar DonetskShakhtar Donetsk | Undisclosed |
| 01 Jul 21 | B. Brobbey Brian Brobbey | Ajax AmsterdamAJA | → | RB LeipzigRBL | Free |
| 01 Jul 21 | N. Kasanwirjo Neraysho Kasanwirjo | Ajax AmsterdamAJA | → |  FC GroningenGRO | Free |
| 01 Jul 21 | N. Marsman Nick Marsman | Feyenoord RotterdamFEY | → | Inter Miami CFMIA | Free |
| 01 Jul 21 | R. Pasveer Remko Pasveer | VitesseVIT | → | Ajax AmsterdamAJA | Free |
| 01 Jul 21 | D. Reiziger Daan Reiziger | Ajax AmsterdamAJA | → | VitesseVIT | Free |
| 01 Jul 21 | Q. Timber Quinten Timber | Ajax AmsterdamAJA | → | FC UtrechtUTR | Free |
| 01 Jul 21 | M. van Ginkel Marco van Ginkel | ChelseaCHE | → | PSV EindhovenPSV | Free |
| 01 Jul 21 | D. Kotarski Dominik Kotarski | Ajax AmsterdamAJA | → | HGXHNK GoricaHNK Gorica | Loan |
| 01 Jul 21 | A. Zagre Arthur Zagre | AS MonacoMON | → | FC UtrechtUTR | Loan |
| 01 Jun 21 | C. Eiting Carel Eiting | Ajax AmsterdamAJA | → |  Racing GenkGENK | Undisclosed |
| 22 Mar 21 | C. Gloster Chris Gloster | PSV EindhovenPSV | → |  New York City FCNYC | Allocation |
| 22 Mar 21 | C. Gloster Chris Gloster | PSV EindhovenPSV | → | New York City FCNYC | Allocation |
| 24 Feb 21 | Q. Promes Quincy Promes | Ajax AmsterdamAJA | → |  Spartak MoscowSPM | Undisclosed |
| 23 Feb 21 | S. van der Water Silvester van der Water |  Heracles AlmeloHER | → |  Orlando City SCORL | Allocation |
| 23 Feb 21 | S. van der Water Silvester van der Water | Heracles AlmeloHER | → | Orlando City SCORL | Allocation |
| 01 Feb 21 | A. Muric Aro Muric | Manchester CityMNC | → | Willem IIWIL | Loan |
| 01 Feb 21 | A. Muric Aro Muric | Manchester CityMNC | → | Willem IIWIL | Loan |
| 01 Feb 21 | O. Idrissi Oussama Idrissi | SevillaSEV | → | Ajax AmsterdamAJA | Loan |
| 01 Feb 21 | O. Idrissi Oussama Idrissi | SevillaSEV | → | Ajax AmsterdamAJA | Loan |
| 19 Jan 21 | K. Huntelaar Klaas-Jan Huntelaar | Ajax AmsterdamAJA | → |  Schalke 04SCHA | Undisclosed |
| 19 Jan 21 | K. Huntelaar Klaas-Jan Huntelaar | Ajax AmsterdamAJA | → | Schalke 04SCHA | Undisclosed |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → | VitesseVIT | Loan |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → | VitesseVIT | Loan |
| 08 Jan 21 | S. Haller Sébastien Haller |  West Ham UnitedWHU | → | Ajax AmsterdamAJA | Undisclosed |
| 08 Jan 21 | S. Haller Sébastien Haller | West Ham UnitedWHU | → | Ajax AmsterdamAJA | Undisclosed |
| 04 Jan 21 | S. de Jong Siem de Jong |  FC CincinnatiCIN | → | HeerenveenHEE | Free |
| 04 Jan 21 | S. de Jong Siem de Jong | FC CincinnatiCIN | → | HeerenveenHEE | Free |