| 31 Aug 21 | C. Richards Chris Richards |  Bayern MunichMUN | → |  TSG HoffenheimHOF | Loan |
| 31 Aug 21 | R. Vita Remy Vita | Bayern MunichMUN | → |  BarnsleyBAR | Loan |
| 31 Aug 21 | R. Hofmann Ron-Thorben Hofmann | Bayern MunichMUN | → |  SunderlandSUN | Loan |
| 31 Aug 21 | A. Lookman Ademola Lookman |  RB LeipzigRBL | → |  Leicester CityLEI | Loan |
| 31 Aug 21 | M. Pongracic Marin Pongracic |  VfL WolfsburgWOB | → |  Borussia DortmundDOR | Loan |
| 31 Aug 21 | I. Moriba Ilaix Moriba |  BarcelonaBAR | → | RB LeipzigRBL | Undisclosed |
| 31 Aug 21 | R. Vita Remy Vita | Bayern MunichMUN | → | BarnsleyBAR | Loan |
| 31 Aug 21 | A. Lookman Ademola Lookman | RB LeipzigRBL | → | Leicester CityLEI | Loan |
| 31 Aug 21 | I. Moriba Ilaix Moriba | BarcelonaBAR | → | RB LeipzigRBL | Undisclosed |
| 30 Aug 21 | A. Zeqiri Andi Zeqiri |  Brighton & Hove AlbionBHA | → |  FC AugsburgAUG | Loan |
| 30 Aug 21 | A. Zeqiri Andi Zeqiri | Brighton & Hove AlbionBHA | → | FC AugsburgAUG | Loan |
| 30 Aug 21 | M. Sabitzer Marcel Sabitzer | RB LeipzigRBL | → | Bayern MunichMUN | Undisclosed |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → |  Wolverhampton WanderersWOL | Loan |
| 29 Aug 21 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → | Wolverhampton WanderersWOL | Loan |
| 27 Aug 21 | J. Ekkelenkamp Jurgen Ekkelenkamp |  Ajax AmsterdamAJA | → |  Hertha BerlinHERT | Undisclosed |
| 27 Aug 21 | J. Ekkelenkamp Jurgen Ekkelenkamp | Ajax AmsterdamAJA | → | Hertha BerlinHERT | Undisclosed |
| 26 Aug 21 | A. Adli Amine Adli |  ToulouseTOUL | → |  Bayer LeverkusenLEV | Undisclosed |
| 25 Aug 21 | A. Sørloth Alexander Sørloth | RB LeipzigRBL | → |  Real SociedadRSO | Loan |
| 25 Aug 21 | M. Cunha Matheus Cunha | Hertha BerlinHERT | → |  Atletico MadridATL | Undisclosed |
| 25 Aug 21 | T. Delaney Thomas Delaney | Borussia DortmundDOR | → |  SevillaSEV | Undisclosed |
| 25 Aug 21 | A. Sørloth Alexander Sørloth | RB LeipzigRBL | → | Real SociedadRSO | Loan |
| 25 Aug 21 | T. Delaney Thomas Delaney | Borussia DortmundDOR | → | SevillaSEV | Undisclosed |
| 25 Aug 21 | M. Cunha Matheus Cunha | Hertha BerlinHERT | → | Atletico MadridATL | Undisclosed |
| 14 Aug 21 | E. Millot Enzo Millot |  AS MonacoMON | → |  Eintracht FrankfurtSGE | Undisclosed |
| 14 Aug 21 | E. Millot Enzo Millot | AS MonacoMON | → | Eintracht FrankfurtSGE | Undisclosed |
| 10 Aug 21 | J. Hauge Jens Hauge |  AC MilanMIL | → | Eintracht FrankfurtSGE | Loan |
| 10 Aug 21 | J. Hauge Jens Hauge | AC MilanMIL | → | Eintracht FrankfurtSGE | Loan |
| 05 Aug 21 | D. Joveljic Dejan Joveljic | Eintracht FrankfurtSGE | → |  LA GalaxyLA | Undisclosed |
| 05 Aug 21 | L. Samardzic Lazar Samardzic | RB LeipzigRBL | → |  LazioLAZ | Undisclosed |
| 05 Aug 21 | D. Joveljic Dejan Joveljic | Eintracht FrankfurtSGE | → | LA GalaxyLA | Undisclosed |
| 05 Aug 21 | L. Samardzic Lazar Samardzic | RB LeipzigRBL | → | LazioLAZ | Undisclosed |
| 04 Aug 21 | L. Bailey Leon Bailey | Bayer LeverkusenLEV | → |  Aston VillaAVL | Undisclosed |
| 04 Aug 21 | L. Bailey Leon Bailey | Bayer LeverkusenLEV | → | Aston VillaAVL | Undisclosed |
| 03 Aug 21 | J. Zirkzee Joshua Zirkzee | Bayern MunichMUN | → |  AnderlechtAND | Loan |
| 27 Jul 21 | D. Malen Donyell Malen |  PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 27 Jul 21 | D. Malen Donyell Malen | PSV EindhovenPSV | → | Borussia DortmundDOR | Undisclosed |
| 24 Jul 21 | T. Jedvaj Tin Jedvaj | Bayer LeverkusenLEV | → |  Lokomotiv MoscowLMO | Undisclosed |
| 23 Jul 21 | J. Sancho Jadon Sancho | Borussia DortmundDOR | → |  Manchester UnitedMAN | Undisclosed |
| 23 Jul 21 | J. Sancho Jadon Sancho | Borussia DortmundDOR | → | Manchester UnitedMAN | Undisclosed |
| 22 Jul 21 | O. Kossounou Odilon Kossounou |  Club BruggeBRUG | → | Bayer LeverkusenLEV | Undisclosed |
| 22 Jul 21 | D. Gray Demarai Gray | Bayer LeverkusenLEV | → |  EvertonEVE | Undisclosed |
| 22 Jul 21 | D. Gray Demarai Gray | Bayer LeverkusenLEV | → | EvertonEVE | Undisclosed |
| 20 Jul 21 | A. Kamara Abdoulaye Kamara |  Paris Saint-Germain PSG | → | Borussia DortmundDOR | Undisclosed |
| 20 Jul 21 | A. Kamara Abdoulaye Kamara | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Undisclosed |
| 17 Jul 21 | L. Nmecha Lukas Nmecha |  Manchester CityMNC | → | VfL WolfsburgWOB | Undisclosed |
| 17 Jul 21 | L. Nmecha Lukas Nmecha | Manchester CityMNC | → | VfL WolfsburgWOB | Undisclosed |
| 14 Jul 21 | A. Fein Adrian Fein | Bayern MunichMUN | → |  SpVgg Greuther FurthFUR | Loan |
| 12 Jul 21 | M. Bakker Mitchel Bakker | Paris Saint-Germain PSG | → | Bayer LeverkusenLEV | Undisclosed |
| 12 Jul 21 | M. Bakker Mitchel Bakker | Paris Saint-Germain PSG | → | Bayer LeverkusenLEV | Undisclosed |
| 03 Jul 21 | L. Balerdi Leonardo Balerdi | Borussia DortmundDOR | → |  MarseilleMAR | Undisclosed |
| 03 Jul 21 | L. Balerdi Leonardo Balerdi | Borussia DortmundDOR | → | MarseilleMAR | Undisclosed |
| 02 Jul 21 | A. Silva André Silva | Eintracht FrankfurtSGE | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | A. Kuol Alou Kuol |  Central Coast MarinersCCM | → |  VfB StuttgartVFB | Free |
| 01 Jul 21 | I. Konaté Ibrahima Konaté | RB LeipzigRBL | → |  LiverpoolLIV | 41500000 |
| 01 Jul 21 | Angeliño | Manchester CityMNC | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | O. Richards Omar Richards |  ReadingREA | → | Bayern MunichMUN | Free |
| 01 Jul 21 | D. Alaba David Alaba | Bayern MunichMUN | → |  Real MadridMAD | Free |
| 01 Jul 21 | N. Ahamada Naouirou Ahamada |  JuventusJUV | → | VfB StuttgartVFB | Undisclosed |
| 01 Jul 21 | J. Toljan Jeremy Toljan | Borussia DortmundDOR | → |  SassuoloSAS | Undisclosed |
| 01 Jul 21 | D. Upamecano Dayot Upamecano | RB LeipzigRBL | → | Bayern MunichMUN | 42500000 |
| 01 Jul 21 | I. Konaté Ibrahima Konaté | RB LeipzigRBL | → | LiverpoolLIV | 41500000 |
| 01 Jul 21 | Angeliño | Manchester CityMNC | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | N. Ahamada Naouirou Ahamada | JuventusJUV | → | VfB StuttgartVFB | Undisclosed |
| 01 Jul 21 | K. Boateng Kevin-Prince Boateng |  MonzaMON | → | Hertha BerlinHERT | Undisclosed |
| 01 Jul 21 | C. Clark Caden Clark |  New York Red BullsNY | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | J. Gvardiol Josko Gvardiol | DZXDinamo ZagrebDinamo Zagreb | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | S. Gómez Sergio Gómez | Borussia DortmundDOR | → | AnderlechtAND | Undisclosed |
| 01 Jul 21 | B. Henrichs Benjamin Henrichs | AS MonacoMON | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | G. Kobel Gregor Kobel | VfB StuttgartVFB | → | Borussia DortmundDOR | Undisclosed |
| 01 Jul 21 | M. Simakan Mohamed Simakan |  StrasbourgSTRA | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | J. Toljan Jeremy Toljan | Borussia DortmundDOR | → | SassuoloSAS | Undisclosed |
| 01 Jul 21 | S. Ulreich Sven Ulreich |  Hamburg SVHSV | → | Bayern MunichMUN | Undisclosed |
| 01 Jul 21 | H. Wolf Hannes Wolf | RB LeipzigRBL | → |  Borussia MonchengladbachMON | Undisclosed |
| 01 Jul 21 | D. Alaba David Alaba | Bayern MunichMUN | → | Real MadridMAD | Free |
| 01 Jul 21 | B. Brobbey Brian Brobbey | Ajax AmsterdamAJA | → | RB LeipzigRBL | Free |
| 01 Jul 21 | Soumaila Coulibaly | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Free |
| 01 Jul 21 | M. Leckie Mathew Leckie | Hertha BerlinHERT | → |  Melbourne City FCMCY | Free |
| 01 Jul 21 | J. Martínez Javi Martínez | Bayer LeverkusenLEV | → | QSXQatar SCQatar SC | Free |
| 01 Jul 21 | L. Piszczek Lukasz Piszczek | Borussia DortmundDOR | → | GXXGoczalkowiceGoczalkowice | Free |
| 01 Jul 21 | O. Richards Omar Richards | ReadingREA | → | Bayern MunichMUN | Free |
| 01 Jul 21 | J. Arp Jann-Fiete Arp | Bayern MunichMUN | → |  Holstein KielHOL | Loan |
| 01 Jul 21 | C. Clark Caden Clark | RB LeipzigRBL | → | New York Red BullsNY | Loan |
| 01 Jul 21 | F. Hartmann Fabrice Hartmann | RB LeipzigRBL | → |  SC Paderborn 07PAD | Loan |
| 01 Jul 21 | L. Mai Lukas Mai | Bayern MunichMUN | → |  Werder BremenWER | Loan |
| 01 Jul 21 | A. Nübel Alexander Nübel | Bayern MunichMUN | → | AS MonacoMON | Loan |
| 01 Jul 21 | B. Henrichs Benjamin Henrichs | AS MonacoMON | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | M. Simakan Mohamed Simakan | StrasbourgSTRA | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | Soumaila Coulibaly | Paris Saint-Germain PSG | → | Borussia DortmundDOR | Free |
| 01 Jul 21 | A. Nübel Alexander Nübel | Bayern MunichMUN | → | AS MonacoMON | Loan |
| 01 Jul 21 | C. Clark Caden Clark | New York Red BullsNY | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 21 | C. Clark Caden Clark | RB LeipzigRBL | → | New York Red BullsNY | Loan |
| 01 Jul 21 | B. Brobbey Brian Brobbey | Ajax AmsterdamAJA | → | RB LeipzigRBL | Free |
| 01 Jul 21 | A. Kuol Alou Kuol | Central Coast MarinersCCM | → | VfB StuttgartVFB | Free |
| 01 Jul 21 | M. Leckie Mathew Leckie | Hertha BerlinHERT | → | Melbourne City FCMCY | Free |
| 04 Mar 21 | M. Edwards Michael Edwards | VfL WolfsburgWOB | → |  Colorado RapidsCOL | Allocation |
| 04 Mar 21 | M. Edwards Michael Edwards | VfL WolfsburgWOB | → | Colorado RapidsCOL | Allocation |
| 01 Feb 21 | Justin Che |  FC DallasDAL | → | Bayern MunichMUN | Loan |
| 01 Feb 21 | N. Radonjic Nemanja Radonjic | MarseilleMAR | → | Hertha BerlinHERT | Loan |
| 01 Feb 21 | C. Richards Chris Richards | Bayern MunichMUN | → | TSG HoffenheimHOF | Loan |
| 01 Feb 21 | J. Zirkzee Joshua Zirkzee | Bayern MunichMUN | → |  ParmaPAR | Loan |
| 01 Feb 21 | N. Radonjic Nemanja Radonjic | MarseilleMAR | → | Hertha BerlinHERT | Loan |
| 01 Feb 21 | S. Khedira Sami Khedira | JuventusJUV | → | Hertha BerlinHERT | Undisclosed |
| 01 Feb 21 | S. Khedira Sami Khedira | JuventusJUV | → | Hertha BerlinHERT | Undisclosed |
| 01 Feb 21 | Justin Che | FC DallasDAL | → | Bayern MunichMUN | Loan |
| 01 Feb 21 | J. Zirkzee Joshua Zirkzee | Bayern MunichMUN | → | ParmaPAR | Loan |
| 31 Jan 21 | D. Gray Demarai Gray | Leicester CityLEI | → | Bayer LeverkusenLEV | Undisclosed |
| 31 Jan 21 | D. Gray Demarai Gray | Leicester CityLEI | → | Bayer LeverkusenLEV | Undisclosed |
| 29 Jan 21 | D. Borkowski Dennis Borkowski | RB LeipzigRBL | → |  NurnbergNUR | Loan |
| 27 Jan 21 | M. Meyer Max Meyer |  Crystal PalaceCRY | → |  FC CologneCOL | Free |
| 27 Jan 21 | M. Meyer Max Meyer | Crystal PalaceCRY | → | FC CologneCOL | Free |
| 21 Jan 21 | J. Mateta Jean-Philippe Mateta |  MainzMAIN | → | Crystal PalaceCRY | Loan |
| 21 Jan 21 | J. Mateta Jean-Philippe Mateta | MainzMAIN | → | Crystal PalaceCRY | Loan |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → |  VitesseVIT | Loan |
| 16 Jan 21 | N. Ohio Noah Ohio | RB LeipzigRBL | → | VitesseVIT | Loan |
| 16 Jan 21 | L. Dajaku Leon Dajaku | Bayern MunichMUN | → |  1. FC Union BerlinFCU | Loan |
| 15 Jan 21 | E. Martel Eric Martel | RB LeipzigRBL | → |  Austria ViennaVIE | Loan |
| 14 Jan 21 | L. Jovic Luka Jovic | Real MadridMAD | → | Eintracht FrankfurtSGE | Loan |
| 14 Jan 21 | L. Jovic Luka Jovic | Real MadridMAD | → | Eintracht FrankfurtSGE | Loan |
| 13 Jan 21 | T. Fosu-Mensah Timothy Fosu-Mensah | Manchester UnitedMAN | → | Bayer LeverkusenLEV | Undisclosed |
| 13 Jan 21 | T. Fosu-Mensah Timothy Fosu-Mensah | Manchester UnitedMAN | → | Bayer LeverkusenLEV | Undisclosed |
| 02 Jan 21 | D. Szoboszlai Dominik Szoboszlai |  FC SalzburgSLZ | → | RB LeipzigRBL | Undisclosed |
| 01 Jan 21 | J. Scally Joe Scally |  New York City FCNYC | → | Borussia MonchengladbachMON | Undisclosed |
| 01 Jan 21 | J. Scally Joe Scally | New York City FCNYC | → | Borussia MonchengladbachMON | Undisclosed |