| 09 Oct 22 | Ø. Nyland Ørjan Nyland | XXX | → |  RB LeipzigRBL | Free |
| 01 Sept 22 | M. Akanji Manuel Akanji |  Borussia DortmundDOR | → |  Manchester CityMNC | Undisclosed |
| 01 Sept 22 | A. Diallo Abdou Diallo |  Paris Saint-Germain PSG | → | RB LeipzigRBL | Loan |
| 01 Sept 22 | I. Moriba Ilaix Moriba | RB LeipzigRBL | → |  ValenciaVAL | Loan |
| 01 Sept 22 | A. Vranckx Aster Vranckx |  VfL WolfsburgWOB | → |  AC MilanMIL | Loan |
| 31 Aug 22 | S. Kalajdzic Sasa Kalajdzic |  VfB StuttgartVFB | → |  Wolverhampton WanderersWOL | Undisclosed |
| 31 Aug 22 | S. Bonnah Owusu Solomon Bonnah Owusu | RB LeipzigRBL | → |  SK Austria KlagenfurtAKL | Undisclosed |
| 31 Aug 22 | R. Pepi Ricardo Pepi |  FC AugsburgFCA | → |  FC GroningenGRO | Loan |
| 30 Aug 22 | G. Vidovic Gabriel Vidovic |  Bayern MunichMUN | → |  VitesseVIT | Loan |
| 30 Aug 22 | S. van den Berg Sepp van den Berg |  LiverpoolLIV | → |  Schalke 04S04 | Loan |
| 30 Aug 22 | B. Arrey-Mbi Bright Arrey-Mbi | Bayern MunichMUN | → |  Hannover 96H96 | Loan |
| 30 Aug 22 | C. Hudson-Odoi Callum Hudson-Odoi |  ChelseaCHE | → |  Bayer LeverkusenB04 | Loan |
| 30 Aug 22 | J. Zirkzee Joshua Zirkzee | Bayern MunichMUN | → |  BolognaBOL | Undisclosed |
| 29 Aug 22 | M. Thiaw Malick Thiaw | Schalke 04S04 | → | AC MilanMIL | Undisclosed |
| 29 Aug 22 | A. Sørloth Alexander Sørloth | RB LeipzigRBL | → |  Real SociedadRSO | Loan |
| 24 Aug 22 | A. Fein Adrian Fein | Bayern MunichMUN | → |  ExcelsiorEXC | Undisclosed |
| 21 Aug 22 | É. Dina-Ebimbe Éric-Junior Dina-Ebimbe | Paris Saint-Germain PSG | → |  Eintracht FrankfurtSGE | Loan |
| 17 Aug 22 | T. Nianzou Tanguy Nianzou | Bayer LeverkusenB04 | → |  SevillaSEV | Undisclosed |
| 12 Aug 22 | F. Kostic Filip Kostic | Eintracht FrankfurtSGE | → |  JuventusJUV | 12000000 |
| 12 Aug 22 | L. Pellegrini Luca Pellegrini | JuventusJUV | → | Eintracht FrankfurtSGE | Loan |
| 09 Aug 22 | T. Werner Timo Werner | ChelseaCHE | → | RB LeipzigRBL | Undisclosed |
| 08 Aug 22 | A. Modeste Anthony Modeste |  FC CologneKOE | → | Borussia DortmundDOR | Undisclosed |
| 08 Aug 22 | Angeliño | RB LeipzigRBL | → |  TSG HoffenheimTSG | Loan |
| 05 Aug 22 | A. Lookman Ademola Lookman | RB LeipzigRBL | → |  AtalantaATA | Undisclosed |
| 31 Jul 22 | O. Mangala Orel Mangala | VfB StuttgartVFB | → |  Nottingham ForestNFO | Undisclosed |
| 31 Jul 22 | D. Raum David Raum | TSG HoffenheimTSG | → | RB LeipzigRBL | Undisclosed |
| 28 Jul 22 | Adam Aznou |  BarcelonaBAR | → | Bayern MunichMUN | Free |
| 27 Jul 22 | V. Palsson Victor Palsson | Schalke 04S04 | → |  D.C. UnitedDC | Undisclosed |
| 27 Jul 22 | C. Richards Chris Richards | Bayern MunichMUN | → |  Crystal PalaceCRY | Undisclosed |
| 27 Jul 22 | K. Mbabu Kevin Mbabu | VfL WolfsburgWOB | → |  FulhamFUL | Undisclosed |
| 26 Jul 22 | N. Mukiele Nordi Mukiele | RB LeipzigRBL | → | Paris Saint-Germain PSG | Undisclosed |
| 26 Jul 22 | M. Tel Mathys Tel |  Stade RennaisREN | → | Bayern MunichMUN | Undisclosed |
| 22 Jul 22 | B. Brobbey Brian Brobbey | RB LeipzigRBL | → |  Ajax AmsterdamAJA | Undisclosed |
| 19 Jul 22 | M. de Ligt Matthijs de Ligt | JuventusJUV | → | Bayern MunichMUN | 67000000 |
| 19 Jul 22 | R. Lewandowski Robert Lewandowski | Bayern MunichMUN | → | BarcelonaBAR | 45000000 |
| 15 Jul 22 | B. Embolo Breel Embolo |  Borussia MonchengladbachBMG | → |  AS MonacoMON | Undisclosed |
| 15 Jul 22 | M. Tillman Malik Tillman | Bayern MunichMUN | → |  RangersRAN | Loan |
| 14 Jul 22 | N. Ohio Noah Ohio | RB LeipzigRBL | → |  Standard LiegeSTL | Undisclosed |
| 13 Jul 22 | Y. Mvogo Yvon Mvogo | RB LeipzigRBL | → |  LorientLOR | Undisclosed |
| 10 Jul 22 | O. Richards Omar Richards | Bayern MunichMUN | → | Nottingham ForestNFO | Undisclosed |
| 06 Jul 22 | A. Witsel Axel Witsel | Borussia DortmundDOR | → |  Atletico MadridATM | Free |
| 06 Jul 22 | S. Haller Sébastien Haller | Ajax AmsterdamAJA | → | Borussia DortmundDOR | Undisclosed |
| 06 Jul 22 | T. Adams Tyler Adams | RB LeipzigRBL | → |  Leeds UnitedLEE | Undisclosed |
| 06 Jul 22 | M. Niakhate Moussa Niakhate |  MainzM05 | → | Nottingham ForestNFO | Undisclosed |
| 02 Jul 22 | K. Itakura Kou Itakura | Manchester CityMNC | → | Borussia MonchengladbachBMG | Undisclosed |
| 01 Jul 22 | T. Krauss Tom Krauss | RB LeipzigRBL | → | Schalke 04S04 | Loan |
| 01 Jul 22 | T. Awoniyi Taiwo Awoniyi |  1. FC Union BerlinFCU | → | Nottingham ForestNFO | Undisclosed |
| 01 Jul 22 | E. Haaland Erling Haaland | Borussia DortmundDOR | → | Manchester CityMNC | Undisclosed |
| 01 Jul 22 | H. Hee-Chan Hwang Hee-Chan | RB LeipzigRBL | → | Wolverhampton WanderersWOL | Undisclosed |
| 01 Jul 22 | S. Mané Sadio Mané | LiverpoolLIV | → | Bayern MunichMUN | Undisclosed |
| 01 Jul 22 | K. Mavropanos Konstantinos Mavropanos |  ArsenalARS | → | VfB StuttgartVFB | Undisclosed |
| 01 Jul 22 | M. Roca Marc Roca | Bayern MunichMUN | → | Leeds UnitedLEE | Undisclosed |
| 01 Jul 22 | J. Kenny Jonjoe Kenny |  EvertonEVE | → |  Hertha BerlinBSC | Free |
| 01 Jul 22 | J. Hauge Jens Hauge | AC MilanMIL | → | Eintracht FrankfurtSGE | Undisclosed |
| 01 Jul 22 | R. Gravenberch Ryan Gravenberch | Ajax AmsterdamAJA | → | Bayern MunichMUN | 18500000 |
| 01 Jul 22 | K. Adeyemi Karim Adeyemi |  FC SalzburgSLZ | → | Borussia DortmundDOR | Undisclosed |
| 01 Jul 22 | S. Drljaca Stefan Drljaca | Borussia DortmundDOR | → |  Dynamo DresdenSGD | Undisclosed |
| 01 Jul 22 | C. Früchtl Christian Früchtl | Bayern MunichMUN | → |  Austria ViennaVIE | Undisclosed |
| 01 Jul 22 | M. Götze Mario Götze |  PSV EindhovenPSV | → | Eintracht FrankfurtSGE | Undisclosed |
| 01 Jul 22 | L. Mai Lukas Mai | Bayern MunichMUN | → |  FC LuganoLUG | Undisclosed |
| 01 Jul 22 | E. Martel Eric Martel | RB LeipzigRBL | → | FC CologneKOE | Undisclosed |
| 01 Jul 22 | S. Ozcan Salih Ozcan | FC CologneKOE | → | Borussia DortmundDOR | Undisclosed |
| 01 Jul 22 | J. Pefok Jordan Pefok |  Young BoysYB | → | 1. FC Union BerlinFCU | Undisclosed |
| 01 Jul 22 | S. Raebiger Sidney Raebiger | RB LeipzigRBL | → |  SpVgg Greuther FurthSGF | Undisclosed |
| 01 Jul 22 | X. Schlager Xaver Schlager | VfL WolfsburgWOB | → | RB LeipzigRBL | Undisclosed |
| 01 Jul 22 | N. Schlotterbeck Nico Schlotterbeck |  SC FreiburgSCF | → | Borussia DortmundDOR | Undisclosed |
| 01 Jul 22 | S. Tigges Steffen Tigges | Borussia DortmundDOR | → | FC CologneKOE | Undisclosed |
| 01 Jul 22 | J. Blaswich Janis Blaswich |  Heracles AlmeloHER | → | RB LeipzigRBL | Free |
| 01 Jul 22 | M. Lotka Marcel Lotka | Hertha BerlinBSC | → | Borussia DortmundDOR | Free |
| 01 Jul 22 | N. Mazraoui Noussair Mazraoui | Ajax AmsterdamAJA | → | Bayern MunichMUN | Free |
| 01 Jul 22 | A. Meyer Alexander Meyer |  SSV Jahn RegensburgREG | → | Borussia DortmundDOR | Free |
| 01 Jul 22 | N. Süle Niklas Süle | Bayern MunichMUN | → | Borussia DortmundDOR | Free |
| 01 Jul 22 | E. Thommy Erik Thommy | VfB StuttgartVFB | → |  Sporting Kansas CitySKC | Free |
| 01 Jul 22 | C. Tolisso Corentin Tolisso | Bayern MunichMUN | → |  LyonLYON | Free |
| 01 Jul 22 | F. Jakel Frederik Jakel | RB LeipzigRBL | → |  Arminia BielefeldDSC | Loan |
| 01 Jul 22 | J. Martínez Josep Martínez | RB LeipzigRBL | → | GXXGenoaGenoa | Loan |
| 01 Jul 22 | T. Schreiber Tim Schreiber | RB LeipzigRBL | → |  Holstein KielKIE | Loan |
| 01 Jul 22 | A. Bella-Kotchap Armel Bella-Kotchap |  VfL BochumBOC | → |  SouthamptonSOU | Undisclosed |
| 09 Feb 22 | C. Clark Caden Clark | RB LeipzigRBL | → |  New York Red BullsNY | Loan |
| 03 Feb 22 | S. Córdova Sergio Córdova | FC AugsburgFCA | → |  Real Salt LakeRSL | Loan |
| 31 Jan 22 | T. Raschl Tobias Raschl | Borussia DortmundDOR | → | SpVgg Greuther FurthSGF | Undisclosed |
| 31 Jan 22 | D. Zakaria Denis Zakaria | Borussia MonchengladbachBMG | → | JuventusJUV | Undisclosed |
| 31 Jan 22 | W. Weghorst Wout Weghorst | VfL WolfsburgWOB | → |  BurnleyBUR | Undisclosed |
| 31 Jan 22 | J. Mateta Jean-Philippe Mateta | MainzM05 | → | Crystal PalaceCRY | Undisclosed |
| 31 Jan 22 | A. Fein Adrian Fein | Bayern MunichMUN | → | Dynamo DresdenSGD | Loan |
| 31 Jan 22 | B. Arrey-Mbi Bright Arrey-Mbi | Bayern MunichMUN | → | FC CologneKOE | Loan |
| 28 Jan 22 | K. Paredes Kevin Paredes | D.C. UnitedDC | → | VfL WolfsburgWOB | Undisclosed |
| 28 Jan 22 | I. Moriba Ilaix Moriba | RB LeipzigRBL | → | ValenciaVAL | Loan |
| 21 Jan 22 | J. Che Justin Che |  FC DallasDAL | → | TSG HoffenheimTSG | Loan |
| 20 Jan 22 | A. Knauff Ansgar Knauff | Borussia DortmundDOR | → | Eintracht FrankfurtSGE | Loan |
| 18 Jan 22 | L. Cândido Luan Cândido | RB LeipzigRBL | → |  Red Bull BragantinoBRA | Undisclosed |
| 18 Jan 22 | J. Meré Jorge Meré | FC CologneKOE | → |  AméricaAME | Undisclosed |
| 08 Jan 22 | F. Blanco Gomez Fabio Gomez | Eintracht FrankfurtSGE | → | BarcelonaBAR | Undisclosed |
| 06 Jan 22 | J. Locadia Jürgen Locadia |  Brighton & Hove AlbionBHA | → | VfL BochumBOC | Undisclosed |
| 04 Jan 22 | B. Brobbey Brian Brobbey | RB LeipzigRBL | → | Ajax AmsterdamAJA | Loan |
| 03 Jan 22 | M. Cuisance Michaël Cuisance | Bayern MunichMUN | → |  VeneziaVEN | Undisclosed |
| 03 Jan 22 | R. Pepi Ricardo Pepi | FC DallasDAL | → | FC AugsburgFCA | Undisclosed |
| 02 Jan 22 | R. Czichos Rafael Czichos | FC CologneKOE | → |  Chicago Fire FCCHI | Undisclosed |