| 07 Oct 21 | N. Nkoulou Nicolas Nkoulou | XXX | → |  WatfordWAT | Free |
| 22 Sept 21 | J. Rodríguez James Rodríguez |  EvertonEVE | → | ARXAl Rayyan Al Rayyan | Undisclosed |
| 09 Sept 21 | Mathias Jorgensen | XXX | → |  BrentfordBRE | Free |
| 02 Sept 21 | F. Anjorin Faustino Anjorin |  ChelseaCHE | → |  Lokomotiv MoscowLMO | Loan |
| 01 Sept 21 | H. Dervisoglu Halil Dervisoglu | BrentfordBRE | → |  GalatasarayGAL | Loan |
| 31 Aug 21 | L. Dendoncker Lars Dendoncker |  Brighton & Hove AlbionBHA | → |  St JohnstoneSTJO | Loan |
| 31 Aug 21 | C. Carter-Vickers Cameron Carter-Vickers |  Tottenham HotspurTOT | → |  CelticCEL | Loan |
| 31 Aug 21 | O. Édouard Odsonne Édouard | CelticCEL | → |  Crystal PalaceCRY | Undisclosed |
| 31 Aug 21 | A. Sima Abdallah Sima | Brighton & Hove AlbionBHA | → |  Stoke CitySTK | Loan |
| 31 Aug 21 | R. Nelson Reiss Nelson |  ArsenalARS | → |  Feyenoord RotterdamFEY | Loan |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk |  Wolverhampton WanderersWOL | → |  Fortuna SittardFOR | Loan |
| 31 Aug 21 | S. Muñoz Santiago Muñoz |  SantosSAN | → |  Newcastle UnitedNEW | Loan |
| 31 Aug 21 | C. Ronan Connor Ronan | Wolverhampton WanderersWOL | → |  St MirrenSTM | Loan |
| 31 Aug 21 | P. Sandler Philippe Sandler |  Manchester CityMNC | → |  TroyesTRY | Loan |
| 31 Aug 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | E. Palmer-Brown Erik Palmer-Brown | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | F. Guilbert Frédéric Guilbert |  Aston VillaAVL | → |  StrasbourgSTRA | Loan |
| 31 Aug 21 | A. Lookman Ademola Lookman |  RB LeipzigRBL | → |  Leicester CityLEI | Loan |
| 31 Aug 21 | D. Praet Dennis Praet | Leicester CityLEI | → |  TorinoTOR | Loan |
| 31 Aug 21 | M. Kean Moise Kean | EvertonEVE | → |  JuventusJUV | Loan |
| 31 Aug 21 | E. Ampadu Ethan Ampadu | ChelseaCHE | → |  VeneziaVEN | Loan |
| 31 Aug 21 | T. Tomiyasu Takehiro Tomiyasu |  BolognaBOL | → | ArsenalARS | Undisclosed |
| 31 Aug 21 | C. Ronaldo Cristiano Ronaldo | JuventusJUV | → |  Manchester UnitedMAN | 15000000 |
| 31 Aug 21 | S. Ñíguez Saúl Ñíguez |  Atletico MadridATL | → | ChelseaCHE | Loan |
| 31 Aug 21 | Y. Herrera Yangel Herrera | Manchester CityMNC | → |  EspanyolESP | Loan |
| 31 Aug 21 | H. Costa Hélder Costa |  Leeds UnitedLEE | → |  ValenciaVAL | Loan |
| 31 Aug 21 | H. Bellerín Héctor Bellerín | ArsenalARS | → |  Real BetisBET | Loan |
| 31 Aug 21 | M. Cucurella Marc Cucurella |  GetafeGET | → | Brighton & Hove AlbionBHA | Undisclosed |
| 31 Aug 21 | E. Royal Emerson Royal |  BarcelonaBAR | → | Tottenham HotspurTOT | 25000000 |
| 31 Aug 21 | R. Williams Rhys Williams |  LiverpoolLIV | → |  Swansea CitySWA | Loan |
| 31 Aug 21 | D. Sterling Dujon Sterling | ChelseaCHE | → |  BlackpoolBLP | Loan |
| 31 Aug 21 | D. Quina Domingos Quina | WatfordWAT | → |  FulhamFUL | Loan |
| 31 Aug 21 | S. Ojo Sheyi Ojo | LiverpoolLIV | → |  MillwallMIL | Loan |
| 31 Aug 21 | R. Khadra Reda Khadra | Brighton & Hove AlbionBHA | → |  Blackburn RoversBLK | Loan |
| 31 Aug 21 | A. Gray Andre Gray | WatfordWAT | → |  Queens Park RangersQPR | Loan |
| 31 Aug 21 | C. Gomes Claudio Gomes | Manchester CityMNC | → |  BarnsleyBAR | Loan |
| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White | Wolverhampton WanderersWOL | → |  Sheffield UnitedSHU | Loan |
| 31 Aug 21 | C. Coventry Conor Coventry |  West Ham UnitedWHU | → |  Peterborough UnitedPET | Loan |
| 31 Aug 21 | X. Silva Xande Silva | West Ham UnitedWHU | → |  Nottingham ForestFOR | Undisclosed |
| 31 Aug 21 | C. Roberts Connor Roberts | Swansea CitySWA | → |  BurnleyBUR | Undisclosed |
| 31 Aug 21 | M. Obafemi Michael Obafemi |  SouthamptonSOU | → | Swansea CitySWA | Undisclosed |
| 31 Aug 21 | N. Chalobah Nathaniel Chalobah | WatfordWAT | → | FulhamFUL | Undisclosed |
| 31 Aug 21 | S. Ñíguez Saúl Ñíguez | Atletico MadridATL | → | ChelseaCHE | Loan |
| 31 Aug 21 | R. Williams Rhys Williams | LiverpoolLIV | → | Swansea CitySWA | Loan |
| 31 Aug 21 | R. Vilca Rodrigo Vilca | Newcastle UnitedNEW | → |  Doncaster RoversDON | Loan |
| 31 Aug 21 | D. Sterling Dujon Sterling | ChelseaCHE | → | BlackpoolBLP | Loan |
| 31 Aug 21 | A. Sima Abdallah Sima | Brighton & Hove AlbionBHA | → | Stoke CitySTK | Loan |
| 31 Aug 21 | P. Sandler Philippe Sandler | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | R. Rúnarsson Rúnar Rúnarsson | ArsenalARS | → |  Oud-Heverlee LeuvenOHL | Loan |
| 31 Aug 21 | C. Ronan Connor Ronan | Wolverhampton WanderersWOL | → | St MirrenSTM | Loan |
| 31 Aug 21 | P. Roberts Patrick Roberts | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | D. Revan Dominic Revan | Aston VillaAVL | → |  Northampton TownNHT | Loan |
| 31 Aug 21 | D. Quina Domingos Quina | WatfordWAT | → | FulhamFUL | Loan |
| 31 Aug 21 | D. Praet Dennis Praet | Leicester CityLEI | → | TorinoTOR | Loan |
| 31 Aug 21 | E. Palmer-Brown Erik Palmer-Brown | Manchester CityMNC | → | TroyesTRY | Loan |
| 31 Aug 21 | A. Oxborough Aston Oxborough |  Norwich CityNOR | → |  BarnetBAR | Loan |
| 31 Aug 21 | S. Ojo Sheyi Ojo | LiverpoolLIV | → | MillwallMIL | Loan |
| 31 Aug 21 | N. Nkounkou Niels Nkounkou | EvertonEVE | → |  Standard LiegeSTL | Loan |
| 31 Aug 21 | R. Nelson Reiss Nelson | ArsenalARS | → | Feyenoord RotterdamFEY | Loan |
| 31 Aug 21 | R. Nartey Richard Nartey | BurnleyBUR | → |  Mansfield TownMAN | Loan |
| 31 Aug 21 | S. Muñoz Santiago Muñoz | SantosSAN | → | Newcastle UnitedNEW | Loan |
| 31 Aug 21 | A. Mair Archie Mair | Norwich CityNOR | → |  Lincoln CityLCN | Loan |
| 31 Aug 21 | A. Lookman Ademola Lookman | RB LeipzigRBL | → | Leicester CityLEI | Loan |
| 31 Aug 21 | N. Lonwijk Nigel Lonwijk | Wolverhampton WanderersWOL | → | Fortuna SittardFOR | Loan |
| 31 Aug 21 | J. Lloyd-Bennett J'Meill Lloyd-Bennett | Tottenham HotspurTOT | → |  Crewe AlexandraCREW | Loan |
| 31 Aug 21 | A. Král Alex Král |  Spartak MoscowSPM | → | West Ham UnitedWHU | Loan |
| 31 Aug 21 | R. Khadra Reda Khadra | Brighton & Hove AlbionBHA | → | Blackburn RoversBLK | Loan |
| 31 Aug 21 | M. Kean Moise Kean | EvertonEVE | → | JuventusJUV | Loan |
| 31 Aug 21 | S. Hughes Sam Hughes | Leicester CityLEI | → |  Burton AlbionBRT | Loan |
| 31 Aug 21 | Y. Herrera Yangel Herrera | Manchester CityMNC | → | EspanyolESP | Loan |
| 31 Aug 21 | P. Gunnarsson Patrik Gunnarsson | BrentfordBRE | → |  Viking FKVIK | Loan |
| 31 Aug 21 | F. Guilbert Frédéric Guilbert | Aston VillaAVL | → | StrasbourgSTRA | Loan |
| 31 Aug 21 | A. Gray Andre Gray | WatfordWAT | → | Queens Park RangersQPR | Loan |
| 31 Aug 21 | C. Gomes Claudio Gomes | Manchester CityMNC | → | BarnsleyBAR | Loan |
| 31 Aug 21 | A. Gilbert Alex Gilbert | BrentfordBRE | → |  Swindon TownSWI | Loan |
| 31 Aug 21 | M. Gibbs-White Morgan Gibbs-White | Wolverhampton WanderersWOL | → | Sheffield UnitedSHU | Loan |
| 31 Aug 21 | T. Doyle Tommy Doyle | Manchester CityMNC | → |  Hamburg SVHSV | Loan |
| 31 Aug 21 | J. Dinzeyi Jonathan Dinzeyi | ArsenalARS | → |  Carlisle UnitedCAR | Loan |
| 31 Aug 21 | L. Dendoncker Lars Dendoncker | Brighton & Hove AlbionBHA | → | St JohnstoneSTJO | Loan |
| 31 Aug 21 | C. Coventry Conor Coventry | West Ham UnitedWHU | → | Peterborough UnitedPET | Loan |
| 31 Aug 21 | H. Costa Hélder Costa | Leeds UnitedLEE | → | ValenciaVAL | Loan |
| 31 Aug 21 | C. Carter-Vickers Cameron Carter-Vickers | Tottenham HotspurTOT | → | CelticCEL | Loan |
| 31 Aug 21 | J. Cain Jake Cain | LiverpoolLIV | → |  Newport CountyNEW | Loan |
| 31 Aug 21 | M. Caicedo Moises Caicedo | Brighton & Hove AlbionBHA | → |  BeerschotBEER | Loan |
| 31 Aug 21 | H. Bellerín Héctor Bellerín | ArsenalARS | → | Real BetisBET | Loan |
| 31 Aug 21 | E. Ampadu Ethan Ampadu | ChelseaCHE | → | VeneziaVEN | Loan |
| 31 Aug 21 | J. Stevens Jordan Stevens | Leeds UnitedLEE | → |  BarrowBRW | Free |
| 31 Aug 21 | S. Rondón Salomón Rondón |  Dalian ProfessionalDAL | → | EvertonEVE | Free |
| 31 Aug 21 | B. Hosannah Bryce Hosannah | Leeds UnitedLEE | → |  WrexhamWRX | Free |
| 31 Aug 21 | R. Gotts Robbie Gotts | Leeds UnitedLEE | → | BarrowBRW | Free |
| 31 Aug 21 | O. Édouard Odsonne Édouard | CelticCEL | → | Crystal PalaceCRY | Undisclosed |
| 31 Aug 21 | N. Vlasic Nikola Vlasic |  CSKA MoscowCSK | → | West Ham UnitedWHU | Undisclosed |
| 31 Aug 21 | T. Tomiyasu Takehiro Tomiyasu | BolognaBOL | → | ArsenalARS | Undisclosed |
| 31 Aug 21 | A. Sima Abdallah Sima | SPXSlavia PragueSlavia Prague | → | Brighton & Hove AlbionBHA | Undisclosed |
| 31 Aug 21 | X. Silva Xande Silva | West Ham UnitedWHU | → | Nottingham ForestFOR | Undisclosed |
| 31 Aug 21 | S. Rondón Salomón Rondón | Dalian ProfessionalDAL | → | EvertonEVE | Undisclosed |
| 31 Aug 21 | C. Roberts Connor Roberts | Swansea CitySWA | → | BurnleyBUR | Undisclosed |
| 31 Aug 21 | M. Obafemi Michael Obafemi | SouthamptonSOU | → | Swansea CitySWA | Undisclosed |
| 31 Aug 21 | D. James Daniel James | Manchester UnitedMAN | → | Leeds UnitedLEE | Undisclosed |
| 31 Aug 21 | M. Cucurella Marc Cucurella | GetafeGET | → | Brighton & Hove AlbionBHA | Undisclosed |
| 31 Aug 21 | N. Chalobah Nathaniel Chalobah | WatfordWAT | → | FulhamFUL | Undisclosed |
| 31 Aug 21 | C. Ronaldo Cristiano Ronaldo | JuventusJUV | → | Manchester UnitedMAN | 15000000 |
| 31 Aug 21 | E. Royal Emerson Royal | BarcelonaBAR | → | Tottenham HotspurTOT | 25000000 |
| 30 Aug 21 | M. Pollock Matthew Pollock | WatfordWAT | → |  Cheltenham TownCHL | |